The danger zone: Systematic review of the role of HMGB1 danger signalling in traumatic brain injury

摘要

Background: Traumatic brain injuries (TBI) are associated with complex inflammatory pathways that lead to the development of secondary injuries such as cerebral ischaemia, elevated intracranial pressure and cognitive deficits. The association between intracellular danger Signalling involving nuclear chromatin-binding factor, high mobility group box-1 (HMGB1) and: inflammatory pathways following TBI has not yet been fully understood.