Repeated predator odor exposure alters maternal behavior of postpartum Brandt's voles and offspring's locomotor activity

摘要

Recent evidence indicates that predation risk plays a special role in the rodent behavior of dams and offspring, but little is known about the effect of maternal exposure to the predator cues in the absence of pups. Here, we assessed the effects of repeated predator odor exposure on various maternal responses in postpartum Branch's voles (Lasiopodomys brandtii). We also examined offspring's behavioral response to a novel environment. Only mother voles were exposed to distilled water, rabbit urine and cat urine for 60 min daily from postpartum day (PP) 1-18. Maternal behavior was immediately tested after these exposures on PP1, 3, 6, 9 and 18. Repeated cat odor (CO) and rabbit odor (RO) exposure disrupted hovering over pups in a time-dependent fashion. Repeated CO exposure also time-dependently disrupted pup retrieval, whereas RO exposure induced long-term reduction in pup licking. Juvenile offspring of CO-exposed mothers showed increased locomotor activity and decreased rearing in the open field at postnatal day 30. These findings demonstrated that maternal exposure to predator or non-predator odors had a disruptive effect on the maternal behavior of Branch's voles when only the mother was exposed to these odors, and that the adversity experience with predation risk significantly impacted the behavioral development of offspring. Future work should explore possible behavioral mechanisms, such as the effect of predation risk, on the dams' emotional processing or pup preference.