Next‐Generation Microbial Workhorses: Comparative Genomic Analysis of Fast‐Growing Vibrio Strains Reveals Their Biotechnological Potential

Peng Yuan; Han Xiao; Xu Ping; Tao Fei

摘要

Abstract > Vibrio is a recognized fast‐growing bacterial genus, which is considered to be attractive for the development of next‐generation biotechnological workhorses. Here, three Vibrio strains FA1, FA2, and FA3, capable of growing rapidly in cost‐effective media, are isolated and systematically evaluated. Genome sequencing and comparative genomic analyses are performed to reveal the underlying genetic differences between the strains and estimate their biotechnological potential. Studies of their phylogenetic tree, colinear visualization, and orthology uncover some difference in the gene content related to cell growth of the four Vibrio strains FA1, FA2, FA3, and ATCC 14048, which may explain growth superiority of the isolated strains. It is noted that there are more copies of several genes related to the DNA replication in the FA2 genome than in the other compared Vibrio strains. Furthermore, the genes responsible for amino synthesis are found, such as asD , within strains FA1 and FA2. Gene cluster cadABC , which relates to cell adaptation at acidic pH, only exists in strains FA1, FA2, and FA3. Finally, the wide spectra of substrates and genetic operability of these three isolated Vibrio strains are initially verified. This study provides excellent candidates for the development of next‐generation fast‐growing microbial workhorses, which may be very useful in synthetic biology. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > vibrio </ i> 是一种公认的快速生长细菌属，这被认为是对下一代生物技术工作人员的发展具有吸引力。在这里，三 vibrio </ i> 菌株Fa1，FA2和FA3能够在经济高效的介质中迅速生长，并分离和系统地评估。进行基因组测序和比较基因组分析以揭示菌株之间的潜在遗传差异并估计其生物技术潜力。它们的系统发育树，Colinear可视化和矫形术中的研究与四肢细胞生长相关的基因含量 vibrio </ i> 菌株FA1，FA2，FA3和ATCC 14048，其可以解释分离的菌株的生长优势。应注意，在FA2基因组中的DNA复制相关的几种基因的副本比另一个基因相关 vibrio </ i> 菌株。此外，找到负责氨基合成的基因，例如 asd </ i> ，在菌株Fa1和Fa2中。基因集群 cadabc </ i> 涉及在酸性pH下的细胞适应涉及菌株Fa1，Fa2和Fa3的细胞适应。最后，底物的宽光谱和这三个分离的遗传可操作性 vibrio </ i> 最初验证了菌株。本研究为下一代快速增长的微生物工作研发提供了优异的候选人，这可能在合成生物学中非常有用。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15025/'>《Biotechnology Journal: Healthcare,Nutrition,Technology》</a> <b style="margin: 0 2px;">|</b><span>2020年第5期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Peng Yuan&option=202" target="_blank" rel="nofollow">Peng Yuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Han Xiao&option=202" target="_blank" rel="nofollow">Han Xiao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xu Ping&option=202" target="_blank" rel="nofollow">Xu Ping;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tao Fei&option=202" target="_blank" rel="nofollow">Tao Fei;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>State Key Laboratory of Microbial MetabolismShanghai Jiao Tong UniversityShanghai 200240 P. R. China;</p> <p>State Key Laboratory of Microbial MetabolismShanghai Jiao Tong UniversityShanghai 200240 P. R. China;</p> <p>State Key Laboratory of Microbial MetabolismShanghai Jiao Tong UniversityShanghai 200240 P. R. China;</p> <p>State Key Laboratory of Microbial MetabolismShanghai Jiao Tong UniversityShanghai 200240 P. R. China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/180.html" title="生物工程学（生物技术）">生物工程学（生物技术）;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=genomic analyses&option=203" rel="nofollow">genomic analyses;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=growth evaluation&option=203" rel="nofollow">growth evaluation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vibrio&option=203" rel="nofollow">Vibrio;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=workhorse&option=203" rel="nofollow">workhorse;</a> </p> <div class="translation"> 机译：基因组分析;生长评估;颤音;主教; 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Al-Musallam</a> <span> <a href="/journal-cn-9411/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 西部皮革 </a> </span> <span> . 2016</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-3319_thesis/02022763237.html">基于比较基因组分析揭示Kosmotoga适应氧化压力的分子机制</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=马诗淳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 马诗淳</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=承磊&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,承磊</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邓宇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,邓宇</a> <span> <a href="/conference-cn-3319/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第五届全国微生物基因组学及合成生物学学术研讨会暨陈华葵先生100周年纪念大会 </a> <span> <span> . 2014</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020315676388.html">利用比较基因组学及全基因组关联分析揭示大豆灰斑病菌侵染机制</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=顾鑫&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 顾鑫</a> <span> . 2020</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120110338015.html">用于分析来自复杂异质群落的微生物菌株、预测并识别其功能关系和相互作用、以及基于其选择并合成微生物群的方法、设备和系统</a> <b>[P]</b> . <span> 中国专利： CN107849597A </span> <span> . 2018-03-27</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061201310164.html">一种基于微生物技术快速酿造葡萄醋的方法</a> <b>[P]</b> . <span> 中国专利： CN101892147B </span> <span> . 2013.12.25</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130401697597.html">Determination of multi-dimensional location, species and genomic copy number by comparative fluorescence imaging of three stained microbial cultures including a lower genomic copy number, slow growth culture</a> <b>[P]</b> . <span> 外国专利：  US10550416B1 </span> <span> . 2020-02-04</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过比较荧光成像对三种染色的微生物培养物（包括较低的基因组拷贝数，缓慢生长的培养物）进行比较荧光成像，确定多维位置，物种和基因组拷贝数 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130436448548.html">Medium for use in detecting a microbial strain in drinking water, comprises nutrients for growing the strain, and at least two chromogens, each of which is a substrate for an enzyme expressed by the strain</a> <b>[P]</b> . <span> 外国专利：  FR2882370A1 </span> <span> . 2006-08-25</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于检测饮用水中微生物菌株的培养基，包括用于使菌株生长的营养物质，以及至少两种色原，每种色原都是菌株表达的酶的底物 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130473246169.html">NOVEL MICROBIAL STRAIN BELONGING TO VIBRIO GENUS AND CAPABLE OF PRODUCING NITROGEN-CONTAINING POLYSACCHARIDE</a> <b>[P]</b> . <span> 外国专利：  JPS59232086A </span> <span> . 1984-12-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：属于弧菌属的新型微生物菌株，可生产含氮多糖 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704021883282','4',7,2,1,'',this,24)" class="delivery" 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