Modeling the Entire Human Mortality Curve: A Regulatory Model of Aging

摘要

—Modeling of the human aging process was performed based on the relationship between overall viability and the processes of growth and self-renewal of tissues, which is presumably regulated by the centers of the vegetative brain. The presence of two regulatory centers, which stimulate and inhibit such growth, as well as the spontaneous degradation of the cells in those centers at different rates, allowed us to simulate the periods of growth, retardation, and decrease of the rate of the growth or self-renewal of tissues. The resulting curve corresponds to the real entire mortality intensity curve for populations, which is known to best describe the growth and aging processes. Such a correspondence between the model and the mortality curve, which is usually described by the Gompertz formula only for the middle part of the curve, was obtained for the first time. The model complies with the regulatory theory of aging and connects aging processes with the processes of regulation of growth and tissue self-renewal.