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首页> 外文期刊>Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie >The effects of neutralizing anti-murine interleukin-17A monoclonal antibody on ozone-induced inflammation and glucocorticoids insensitivity in a murine model of asthma
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The effects of neutralizing anti-murine interleukin-17A monoclonal antibody on ozone-induced inflammation and glucocorticoids insensitivity in a murine model of asthma

机译：中和抗鼠白细胞介素-17A单克隆抗体对哮喘小鼠模型中臭氧诱导炎症和糖皮质激素的影响

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摘要

Background and objective: Exposure to ozone contributed to the worsening of inflammation and glucocorticoids insensitivity in OVA-challenged asthma. Interleukin-17A participates centrally in stages of the inflammatory response and glucocorticoids insensitivity. In this study, the effect of neutralizing anti-murine interleukin-17A monoclonal antibody (IL-17A mAb) on inflammation and glucocorticoids insensitivity in ozone-exposed and ovalbumin (OVA)-challenged mice was investigated.
机译：背景和目的：暴露于臭氧导致炎症和糖皮质激素在卵子攻击性哮喘中的不敏感性。 白细胞介素-17A参与炎症反应的阶段和糖皮质激素不敏感性的阶段。 在该研究中，研究了中和抗鼠白细胞介素-17a单克隆抗体（IL-17a mAb）对臭氧和卵蛋白（OVA）挑剔的小鼠炎症和糖皮质激素的影响。

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  • 来源
  • 作者

    Zhang Yingying; Li Xingjing; He Mudan; Zhang Guoqing; Bao Wuping; Fei Xia; Zhang Xue; Zhang Min; Zhang Pengyu;

  • 作者单位

    Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Resp &

    Crit Care Med 100 Haining Rd Shanghai;

    Shanghai First Peoples Hosp Baoshan Branch Dept Resp Med Shanghai Peoples R China;

    Shanghai First Peoples Hosp Baoshan Branch Dept Resp Med Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Resp &

    Crit Care Med 100 Haining Rd Shanghai;

    Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Resp &

    Crit Care Med 100 Haining Rd Shanghai;

    Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Resp &

    Crit Care Med 100 Haining Rd Shanghai;

    Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Resp &

    Crit Care Med 100 Haining Rd Shanghai;

    Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Resp &

    Crit Care Med 100 Haining Rd Shanghai;

    Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Resp &

    Crit Care Med 100 Haining Rd Shanghai;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 治疗学;
  • 关键词

    IL-17A monoclonal antibody; Glucocorticoid; Ozone; Asthma; Inflammation;

    机译：IL-17A单克隆抗体;糖皮质激素;臭氧;哮喘;炎症;

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