A-1S A NEW METHOD OF BILIARY TISSUE SAMPLING FOR CYTOPATHOLOGIC EXAMINATION DURING ENDOSCOPIC RETROGRADE CHOLANGIOGRAPHY

摘要

Biliary brushing during endoscopic retrograde cliolangiography (ERC) may allow diagnosis of cancer, but this technique is limited by a tow (18-57%) sensitivity. We compared the cellular and diagnostic yields of a new sampling method (using stricture dilation and a grasping basket) to those of brushing. METHODS: Sixty consecutive patients with a suspected malignant obstruction of the common bile duct were included in the study in a consecutive, nonrandomized, order. They underwent sampling during ERC using the new method (study patients, n = 30) or a brush (control patients, n = 30). A final diagnosis of cancer was made in 22 of 30 (73%) study patients and 21 of 30 (70%) control patients. At the end of the study period, all smears were interpreted at cy-topathologic examination in a blind and random fashion for cellu-larity (insufficient, low, moderate, or high) and diagnosis (normal, atypical considered reactive, highly atypical suspicious for cancer, or malignant).