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首页> 外文期刊>Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie >Down-regulated miR-148b increases resistance to CHOP in diffuse large B-cell lymphoma cells by rescuing Ezrin
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Down-regulated miR-148b increases resistance to CHOP in diffuse large B-cell lymphoma cells by rescuing Ezrin

机译：下调的miR-148b通过拯救ezrin来增加弥漫性大B细胞淋巴瘤细胞的抗性

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摘要

Background: Aberrant microRNA (miRNAs) have recently been proposed as important regulators in acquiring resistance to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in diffuse large B-cell lymphoma (DLBCL). The purpose of this study was to establish the role of miR-148b in the development of CHOP resistance in DLBCL.
机译：背景：最近已经提出了异常微小RNA（MIRNA）作为在弥漫性大B细胞淋巴瘤（DLBCL）中获得对环磷酰胺，多柔比蛋白，长春螯合物和泼尼松（CHPO）抗性的重要调节剂。 本研究的目的是建立miR-148b在DLBCL中斩波抗性发展中的作用。

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    Sun Ni; Wang Chen-Yi; Sun Yi-Qun; Ruan Ye-Jiao; Huang Yue-Yue; Su Tong; Zhou Xiao-Hai; Huang He; Guo Wen-Jian; He Mu-Qing; Yao Rong-Xin; Lin Xiao-Ji;

  • 作者单位

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

    Wenzhou Med Univ Affiliated Hosp 2 Dept Haematol 109 Xueyuan Rd Wenzhou 325000 Zhejiang;

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  • 正文语种 eng
  • 中图分类 治疗学 ;
  • 关键词

    DLBCL; CHOP resistance; MiR-148b; Ezrin; HDAC6;

    机译：DLBCL;斩波阻力;miR-148b;ezrin;hdac6;

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