Medical and Microbial Applications of Controlled Shape of Silver Nanoparticles Prepared by Ionizing Radiation

摘要

New strategies are needed to develop new drugs to treat emerging infectious diseases and microbial resistance. A new effective strategy is to design drugs combined with metal nanoparticles to overcome infections of multidrug-resistant microbes. In this study, we investigated the anti-microbial and anticancer properties of three differently shaped silver nanoparticles (S1-S3) against a wide range of microorganisms as well as two types of carcinoma cells. The three forms of silver nanoparticles (Ag-NPs) were investigated against Coxsackievirus B3 and 5 fungal strains (Aspergillus fumigatus, Candida albicans, Geotricum candidum, Aspergillus niger, Trichophyton mentagrophytes) while for antibacterial and anticancer evaluation, S2 was used. Our results demonstrated that all forms had antiviral activities against virus replication with TI ranging from 0.4 to 30 and reduction in virus titers ranged from 0 to 4 log_(10) TCID_(50). On the other hand, only Ag-NPs S2 exhibited antifungal activities, mostly against Trichophyton mentagrophytes. Also, Ag-NP S2 showed antibacterial effects against some gram-negative bacteria (Escherichia coli, Acinetobacter baumannii, Klebsiella pneumonia, Salmonella typhi, and Enterobacter cloacae) and some positive bacteria (Bacillus subtilis, Staphylococcus aureus, Streptococcus mutans). Furthermore, Ag-NPs displayed a significant cytotoxic potential in cancerous Hep-G2 and A549 cell lines. The results obtained demonstrate that Ag-NPs can be utilized as strong antimicrobial and anticancer agents.