CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal

Saravia Rocio; Flores Africa; Plaza-Zabala Ainhoa; Busquets-Garcia Arnau; Pastor Antoni; de la Torre Rafael; Di Marzo Vincenzo; Marsicano Giovanni; Ozaita Andres; Maldonado Rafael; Berrendero Fernando

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CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal

机译：CB1大麻素受体在尼古丁戒断过程中介导认知缺陷和结构可塑性变化

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BACKGROUND: Tobacco withdrawal is associated with deficits in cognitive function, including attention, working memory, and episodic memory. Understanding the neurobiological mechanisms involved in these effects is crucial because cognitive deficits during nicotine withdrawal may predict relapse in humans.

机译：背景：烟草提取与认知功能的缺陷相关，包括注意，工作记忆和集体记忆。了解这些效果中涉及的神经生物学机制至关重要，因为尼古丁戒断期间的认知缺陷可能预测人类的复发。

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来源
《Biological psychiatry》 |2017年第7期|共10页
作者
Saravia Rocio; Flores Africa; Plaza-Zabala Ainhoa; Busquets-Garcia Arnau; Pastor Antoni; de la Torre Rafael; Di Marzo Vincenzo; Marsicano Giovanni; Ozaita Andres; Maldonado Rafael; Berrendero Fernando;
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作者单位

Univ Pompeu Fabra Dept Expt &

Hlth Sci Neuropharmacol Lab PRBB Doctor Aiguader 88 Barcelona;

Univ Pompeu Fabra Dept Expt &

Hlth Sci Neuropharmacol Lab PRBB Doctor Aiguader 88 Barcelona;

Univ Pompeu Fabra Dept Expt &

Hlth Sci Neuropharmacol Lab PRBB Doctor Aiguader 88 Barcelona;

Univ Pompeu Fabra Dept Expt &

Hlth Sci Neuropharmacol Lab PRBB Doctor Aiguader 88 Barcelona;

IMIM Hosp Mar Med Res Inst Integrat Pharmacol &

Syst Neurosci Barcelona Spain;

IMIM Hosp Mar Med Res Inst Integrat Pharmacol &

Syst Neurosci Barcelona Spain;

CNR Inst Biomol Chem Endocannabinoid Res Grp Naples Italy;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat Grp U1215 F-75654 Paris 13 France;

Univ Pompeu Fabra Dept Expt &

Hlth Sci Neuropharmacol Lab PRBB Doctor Aiguader 88 Barcelona;

Univ Pompeu Fabra Dept Expt &

Hlth Sci Neuropharmacol Lab PRBB Doctor Aiguader 88 Barcelona;

Univ Pompeu Fabra Dept Expt &

Hlth Sci Neuropharmacol Lab PRBB Doctor Aiguader 88 Barcelona;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
CB1R; Cognition; Knockout mice; Nicotine; Plasticity; Withdrawal;

机译：CB1R;认知;敲除老鼠;尼古丁;可塑性;撤回;

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专利

1. CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal [J] . Saravia Rocio, Flores Africa, Plaza-Zabala Ainhoa, Biological psychiatry . 2017,第7期

机译：CB1大麻素受体在尼古丁戒断过程中介导认知缺陷和结构可塑性变化
2. Nicotine-Associated Cues Maintain Nicotine-Seeking Behavior in Rats Several Weeks after Nicotine Withdrawal: Reversal by the Cannabinoid (CB1) Receptor Antagonist, Rimonabant (SR141716) [J] . Caroline Cohen, Ghislaine Perrault, Guy Griebel, Neuropsychopharmacology . 2005,第1期

机译：尼古丁相关的线索在尼古丁戒断后几周维持大鼠的尼古丁寻找行为：大麻素（CB1）受体拮抗剂利莫那班（Rimonabant）逆转（SR141716）
3. Basolateral amygdala CB1 cannabinoid receptors mediate nicotine-induced place preference [J] . Shiva Hashemizadeh, Maryam Sardari, Ameneh Rezayof Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal . 2014,第Null期

机译：基底外侧杏仁核CB1大麻素受体介导烟碱诱导的位置偏爱
4. THE ROLE OF ANANDAMIDE AND RELATED FATTY ACID ETHANOLAMIDES AS ENDOGENOUS LIGANDS FOR THE CB1 AND CB2 CANNABINOID RECEPTORS [C] . Christian C. Felder, Amie Nielsen, Eileen M. Briley, International Washington Spring Symposium . 1996

机译：Anandamide和相关脂肪酸乙醇酰胺作为CB1和CB2大麻素受体的内源配体的作用
5. Nicotine Withdrawal and Deficits in Cognitive Flexibility: Possible Ties to Aberrations in Frontostriatal BDNF Signaling. [D] . Cole, Robert D. 2017

机译：尼古丁戒断和认知灵活性的不足：可能与额骨BDNF信号畸变有关。
6. The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons [O] . Christian Njoo, Nitin Agarwal, Beat Lutz, 2015

机译：大麻受体CB1与WAVE1复合物相互作用并在神经元的肌动蛋白动力学和结构可塑性中发挥作用
7. CB1 cannabinoid receptors mediate cognitive deficits and structural plasticity changes during nicotine withdrawal [O] . Saravia, Rocío, Flores de los Heros, África, 1985-, Plaza-Zabala, Ainhoa, 1982-, 2017

机译：CB1大麻素受体介导尼古丁戒断期间的认知缺陷和结构可塑性变化
8. Epidermal Growth Factor Receptor Transactivation by the Cannabinoid Receptor (CB1) and Transient Receptor Potential Vanilloid 1 (TRPV1) Induces Differential Responses in Corneal Epithelial Cells [R] . Yang, H., Wang, Z., Capo-Aponte, J. E., 2010

机译：大麻素受体（CB1）和瞬时受体电位香草酸1（TRpV1）的表皮生长因子受体反式激活诱导角膜上皮细胞的差异反应

CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal

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