A Role for Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 alpha in Nucleus Accumbens Neuron Subtypes in Cocaine Action

摘要

BACKGROUND: Molecules critically involved in cocaine behavioral plasticity are known to regulate and interact with peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha). In addition, the PGC-1a promoter has binding sites for early growth response 3 (Egr3), which plays a dynamic role in cocaine action in nucleus accumbens (NAc) medium spiny neuron (MSN) subtypes, those enriched in dopamine receptor D1 (D1-MSN) versus D-2 (D2-MSN). However, the role of PGC-1 alpha in NAc in cocaine action is unknown.