Wnt/β-catenin signaling links embryonic lung development and asthmatic airway remodeling

摘要

Abstract Embryonic lung development requires reciprocal endodermal-mesodermal interactions; mediated by various signaling proteins. Wnt/β-catenin is a signaling protein that exhibits the pivotal role in lung development, injury and repair while aberrant expression of Wnt/β-catenin signaling leads to asthmatic airway remodeling: characterized by hyperplasia and hypertrophy of airway smooth muscle cells, alveolar and vascular damage goblet cells metaplasia, and deposition of extracellular matrix; resulting in decreased lung compliance and increased airway resistance. The substantial evidence suggests that Wnt/β-catenin signaling links embryonic lung development and asthmatic airway remodeling. Here, we summarized the recent advances related to the mechanistic role of Wnt/β-catenin signaling in lung development, consequences of aberrant expression or deletion of Wnt/β-catenin signaling in expansion and progression of asthmatic airway remodeling, and linking early-impaired pulmonary development and airway remodeling later in life. Finally, we emphasized all possible recent potential therapeutic significance and future prospectives, that are adaptable for therapeutic intervention to treat asthmatic airway remodeling. Highlights ? Wnt/β-catenin is obligatory for embryonic lung morphogenesis and development. ? Aberrant activation of Wnt/β-catenin signaling leads to asthmatic airway remodeling. ? Wnt/β-catenin signaling links lung development and asthmatic airway remodeling. ? Blocking Wnt/β-catenin signaling prevents asthmatic airway remodeling.