Glutathione S-transferase circle minus-subunit as a phenotypic suppressor of pmr1 Delta strain, the Kluyveromyces lactis model for Hailey-Hailey disease

摘要

Background: Hailey-Hailey disease (HHD), also known as familial benign chronic pemphigus, is a rare, chronic and recurrent blistering disorder, histologically characterized by suprabasal acantholysis. HHD has been linked to mutations in ATP2C1, the gene encoding the human adenosine triphosphate (ATP)-powered calcium channel pump.