INSULIN, INDEPENDENT OF SERUM ANDROGENS OR ANDROGEN RECEPTOR CAG REPEAT POLYMORPHISM, IS ASSOCIATED WITH HIRSUTISM IN POLYCYSTIC OVARY SYNDROME

摘要

Background. Hirsutism is part of current criteria of polycystic ovary syndrome (PCOS), as a clinical expression of hyperandrogenism. Objective. To evaluate the significant factors for hirsutism severity in PCOS. Patients. A total of 235 PCOS patients, consecutively coming for medical advice, aged 18-35 yrs, all of Romanian origin, were diagnosed according to Rotterdam criteria. Methods. Hirsutism, quantified using the modified Ferriman-Gallwey (mFG) procedure, was defined by values equal or more than 6. Other parameters evaluated were: body mass index (BMI), fasting insulinemia, insulin resistance quantified by QUICKI, total testosterone (TT), free androgen index (FAI), dehydroepiandrosterone sulfate (DHEAs), 17OH progesterone, fasting glycemia. In a subset of 106 patients, androgen receptor (AR) was explored by CAG repeat genotyping and X-chromosome inactivation analysis.