Direct access to 1,4-disubstituted 1,2,3-triazoles through organocatalytic 1,3-dipolar cycloaddition reaction of alpha,beta-unsaturated esters with azides

摘要

DBU-catalyzed organocatalytic 1,3-dipolar cycloaddition reactions of alpha, beta-unsaturated esters with azides have been developed. This strategy generates 1,4-disubstituted 1,2,3-triazoles in high yields with high regioselectivities. It is demonstrated that some of these products can be transformed into important pharmaceutical agents.