Modular construction of multifunctional ligands for the enantioselective ruthenium-catalyzed carbenoid N-H insertion reaction: an enzyme-like and substrate-sensitive catalyst system

摘要

It was found for the first time that cinchonine-and BINOL-derived multifunctional ligands bearing a siliconbased bulky group exhibited promising enantioselective control in the ruthenium-catalysed carbenoid N-H insertion reaction, in which the Ru-L26 system with multiple stereogenic centers was proved to be an enzyme-like catalyst because it exhibited a narrow substrate scope and size-sensitive discrimination in this reaction.