Cu(II)-catalyzed cross-dehydrogenative coupling reaction of N '-acyl arylhydrazines and phosphites

摘要

A novel Cu(II)-catalyzed cross-dehydrogenative coupling reaction of N'-aryl acylhydrazines and dialkyl phosphites has been developed for the synthesis of phosphorylhydrazides by using NMO as an external oxidant and AgNO3 as additive. Various N'-aryl acylhydrazines were mildly and regioselectively converted to corresponding phosphorylhydrazides with good to excellent yields.