Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD

Biswal Manas R.; Han Pingyang; Zhu Ping; Wang Zhaoyang; Li Hong; Ildefonso Cristhian J.; Lewin Alfred S.

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Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD

机译：抗氧化基因疗法的时间：治疗干燥AMD的含义

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PURPOSE. To investigate whether antioxidant gene therapy protects the structure and function of retina in a murine model of RPE atrophy, and to determine whether antioxidant gene therapy can prevent degeneration once it has begun.

机译：目的。为了探讨抗氧化基因治疗是否保护RPE萎缩的鼠模型中视网膜的结构和功能，并确定抗氧化剂基因治疗是否可以防止退化。

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来源
《Investigative ophthalmology & visual science 》 |2017年第2期| 共9页
作者
Biswal Manas R.; Han Pingyang; Zhu Ping; Wang Zhaoyang; Li Hong; Ildefonso Cristhian J.; Lewin Alfred S.;
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作者单位

Univ Florida Coll Med Dept Mol Genet &

Microbiol 1200 Newell Dr Gainesville FL 32610 USA;

Univ Florida Coll Med Dept Mol Genet &

Microbiol 1200 Newell Dr Gainesville FL 32610 USA;

Univ Florida Coll Med Dept Ophthalmol Gainesville FL 32610 USA;

Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Dept Ophthalmol Shanghai Peoples R;

Univ Florida Coll Med Dept Mol Genet &

Microbiol 1200 Newell Dr Gainesville FL 32610 USA;

Univ Florida Coll Med Dept Ophthalmol Gainesville FL 32610 USA;

Univ Florida Coll Med Dept Mol Genet &

Microbiol 1200 Newell Dr Gainesville FL 32610 USA;

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原文格式 PDF
正文语种 eng
中图分类眼科学 ;
关键词
gene therapy; age-related macular degeneration; superoxide dismutase 2; retinal pigment epithelium; geographic atrophy;

机译：基因疗法;年龄相关的黄斑变性;超氧化物歧化酶2;视网膜色素上皮;地理萎缩;

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专利

1. Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD [J] . Manas R. Biswal, Pingyang Han, Ping Zhu, Investigative ophthalmology & visual science . 2017 ,第2期

机译：抗氧化基因疗法的时机：对治疗干性AMD的意义
2. Development of Age-Related Macular Degeneration (AMD) in the Fellow Eye of Patients with AMD Treated by Treat-and-Extend Intravitreal Therapy with Aflibercept [J] . Kensuke Mimura, Hidetaka Matsumoto, Masahiro Morimoto, Ophthalmologica: International Journal of Ophthalmology=Journal International d'Ophtalmologie . 2018 ,第2a3期

机译：通过AFLibercept治疗AMD治疗患者的患者同源患者的年龄相关性黄斑变性（AMD）
3. GMP-grade production of tIPE, a cell-based gene therapy product to treat neovascular age-related macular degeneration (nvAMD) developed in the TargetAMD project [J] . Kropp M., Harmening N., Bascuas T., Human gene therapy . 2018 ,第12期

机译：GMP级生产的肥料，一种基于细胞的基因治疗产品，以治疗在Targetamd项目中开发的新生血管年龄相关的黄斑变性（NVAMD）
4. Oxidants/antioxidants and chronic obstructive pulmonary disease: pathogenesis to therapy [C] . William MacNee Workshop on Genome Informatics . 2000

机译：氧化剂/抗氧化剂和慢性阻塞性肺病：治疗发病机制
5. A model for choroidal neovascularization (CNV) and gene therapy for age-related macular degeneration (AMD). [D] . Wang, Fei. 2001

机译：脉络膜新生血管（CNV）和年龄相关性黄斑变性（AMD）基因治疗的模型。
6. Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD [O] . Manas R. Biswal, Pingyang Han, Ping Zhu, -1

机译：抗氧化基因疗法的时机：对治疗干性AMD的意义
7. Quality of life in patients with dry age-related macular degeneration (dry AMD) treated with intravitreal bone marrow-derived stem cells (AMDCELL-clinical trial) [O] . Rubens C Siqueira, Carina C Cotrim, Luiza Toscano, 2019

机译：用玻璃体内骨髓衍生干细胞治疗干燥年龄相关性黄斑（Dry AMD）的患者的生活质量（Amdcell临床试验）

Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD

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