Therapeutic Effects of PPAR alpha Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration

Qiu Fangfang; Matlock Greg; Chen Qian; Zhou Kelu; Du Yanhong; Wang Xiang; Ma Jian-Xing

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Therapeutic Effects of PPAR alpha Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration

机译：PPARα激动剂对综合新生血管年龄相关性黄斑变性的模型眼血管形成的治疗效果

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PURPOSE. This study was designed to evaluate effects of fenofibric acid (Feno-FA), a peroxisome proliferator-activated receptor-alpha (PPAR alpha) agonist, on ocular neovascularization (NV) in models recapitulating neovascular age-related macular degeneration (AMD), and to explore whether the effects are PPAR alpha dependent.

机译：目的。本研究旨在评估未纤维酸（FENo-FA），过氧化物体增殖物激活的受体-α（PPARα）激动剂在综合性新生血管年龄相关性黄斑变性（AMD）的模型中的眼新血管体化（NV）的效果。探索效果是否依赖于PPAR alpha。

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来源
《Investigative ophthalmology & visual science》 |2017年第12期|共11页
作者
Qiu Fangfang; Matlock Greg; Chen Qian; Zhou Kelu; Du Yanhong; Wang Xiang; Ma Jian-Xing;
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作者单位

Univ Oklahoma Hlth Sci Ctr Dept Physiol 941 Stanton L Young Blvd BSEB 328B Oklahoma City OK;

Univ Oklahoma Hlth Sci Ctr Dept Physiol 941 Stanton L Young Blvd BSEB 328B Oklahoma City OK;

Univ Oklahoma Hlth Sci Ctr Dept Physiol 941 Stanton L Young Blvd BSEB 328B Oklahoma City OK;

Univ Oklahoma Hlth Sci Ctr Dept Physiol 941 Stanton L Young Blvd BSEB 328B Oklahoma City OK;

Univ Oklahoma Hlth Sci Ctr Dept Physiol 941 Stanton L Young Blvd BSEB 328B Oklahoma City OK;

Univ Oklahoma Hlth Sci Ctr Dept Cell Biol Oklahoma City OK USA;

Univ Oklahoma Hlth Sci Ctr Dept Physiol 941 Stanton L Young Blvd BSEB 328B Oklahoma City OK;

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原文格式 PDF
正文语种 eng
中图分类眼科学;
关键词
age-related macular degeneration; PPAR alpha; fenofibrate; inflammation; retina; neovascularization;

机译：年龄相关的黄斑变性;PPARα;芬纤维;炎症;视网膜;新生血管;

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1. Therapeutic Effects of PPAR alpha Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration [J] . Qiu Fangfang, Matlock Greg, Chen Qian, Investigative ophthalmology & visual science . 2017,第12期

机译：PPARα激动剂对综合新生血管年龄相关性黄斑变性的模型眼血管形成的治疗效果
2. Therapeutic Effects of PPAR alpha Agonist on Experimental Neovascular Age-Related Macular Degeneration [J] . Qiu Fangfang, Matlock H. Greg, Chen Qian, Investigative ophthalmology & visual science . 2017,第8期

机译：PPARα激动剂对实验新生血管年龄相关性黄斑变性的治疗效果
3. Therapeutic Effects of PPAR alpha Agonist on Experimental Neovascular Age-Related Macular Degeneration [J] . Qiu Fangfang, Matlock H. Greg, Chen Qian, Investigative ophthalmology & visual science . 2017,第8期

机译：PPARα激动剂对实验新生血管年龄相关性黄斑变性的治疗效果
4. Assessment of Choroidal Neovascular Membranes Secondary to Age-Related Macular Degeneration Using Feature Selection [C] . E. Brankin, P.J. McCullagh, W.P. Patton European Conference of the International Federation for Medical and Biological Engineering . 2013

机译：用特征选择评估二次与年龄相关黄斑变性的脉络膜新生血管膜
5. A model for choroidal neovascularization (CNV) and gene therapy for age-related macular degeneration (AMD). [D] . Wang, Fei. 2001

机译：脉络膜新生血管（CNV）和年龄相关性黄斑变性（AMD）基因治疗的模型。
6. Therapeutic Effects of PPARα Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration [O] . Fangfang Qiu, Greg Matlock, Qian Chen, -1

机译：PPARα激动剂对新生血管性年龄相关性黄斑变性模型中眼新血管形成的治疗作用
7. Therapeutic Effects of PPARα Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration [O] . Fangfang Qiu, Greg Matlock, Qian Chen, 2017

机译：PPARα激动剂对综合血管时代相关黄斑变性模型眼血管形成的疗效

Therapeutic Effects of PPAR alpha Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration

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