Extended preclinical ocular biodistribution and pharmacodynamic profile of ISTH0036, an antisense oligonucleotide targeting transforming growth factor beta 2 (TGF-beta 2) for the treatment of ophthalmic diseases

Wosikowski Katja; Korbmacher Birgit; Krampert Monika; Roehl Ingo; Janicot Michel

首页> 外文期刊>Investigative ophthalmology & visual science >Extended preclinical ocular biodistribution and pharmacodynamic profile of ISTH0036, an antisense oligonucleotide targeting transforming growth factor beta 2 (TGF-beta 2) for the treatment of ophthalmic diseases

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Extended preclinical ocular biodistribution and pharmacodynamic profile of ISTH0036, an antisense oligonucleotide targeting transforming growth factor beta 2 (TGF-beta 2) for the treatment of ophthalmic diseases

机译：ISTH0036的延伸临床前眼部生物分布和药效学分布，靶向转化生长因子β2（TGF-Beta 2）的反义寡核苷酸用于治疗眼科疾病

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来源
《Investigative ophthalmology & visual science》 |2018年第9期|共2页
作者
Wosikowski Katja; Korbmacher Birgit; Krampert Monika; Roehl Ingo; Janicot Michel;
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作者单位

Isarna Therapeut Preclin Res &

Dev Munich Germany;

Covance Preclin Serv GmbH Munster Germany;

LGC AxoLabs Kulmbach Germany;

LGC AxoLabs Kulmbach Germany;

Isarna Therapeut Preclin Res &

Dev Munich Germany;

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原文格式 PDF
正文语种 eng
中图分类眼科学;
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1. Extended preclinical ocular biodistribution and pharmacodynamic profile of ISTH0036, an antisense oligonucleotide targeting transforming growth factor beta 2 (TGF-beta 2) for the treatment of ophthalmic diseases [J] . Wosikowski Katja, Korbmacher Birgit, Krampert Monika, Investigative ophthalmology & visual science . 2018,第9期

机译：ISTH0036的延伸临床前眼部生物分布和药效学分布，靶向转化生长因子β2（TGF-Beta 2）的反义寡核苷酸用于治疗眼科疾病
2. Combining ISTH0036, an antisense oligonucleotide targeting Transforming Growth Factor beta 2 (TGF-beta 2) mRNA, with aflibercept as novel treatment strategy for neovascular retinal diseases [J] . Janicot Michel, Kalesnykas Giedrius, Leo Eugen, Investigative ophthalmology & visual science . 2018,第9期

机译：组合ISTH0036，靶向转化生长因子β2（TGF-β2）mRNA的反义寡核苷酸，与AfliBercept作为新生血管视网膜疾病的新型治疗策略
3. Combining ISTH0036, an antisense oligonucleotide targeting Transforming Growth Factor beta 2 (TGF-beta 2) mRNA, with aflibercept as novel treatment strategy for neovascular retinal diseases [J] . Janicot Michel, Kalesnykas Giedrius, Leo Eugen, Investigative ophthalmology & visual science . 2018,第9期

机译：组合ISTH0036，靶向转化生长因子β2（TGF-β2）mRNA的反义寡核苷酸，与AfliBercept作为新生血管视网膜疾病的新型治疗策略
4. Transforming growth factor beta in the treatment of autoimmune disease [C] . International Symposium on the Maillard Reaction . 2002

机译：转化生长因子β在治疗自身免疫性疾病中
5. Transforming growth factor-beta1 activation and transforming growth factor-beta receptor 2 expression levels in the regulation of the TGF-beta signaling pathway. [D] . Rojas, Andres. 2008

机译：在调节TGF-beta信号通路中转化生长因子-beta1激活和转化生长因子-beta受体2的表达水平。
6. First-in-human phase I study of ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in subjects with open-angle glaucoma undergoing glaucoma filtration surgery [O] . Norbert Pfeiffer, Bogomil Voykov, Giulia Renieri, 2011

机译：在患有青光眼滤过手术的开角型青光眼患者中进行的人类首次I期研究ISTH0036（一种选择性靶向转化生长因子β2（TGF-β2）的反义寡核苷酸）
7. First-in-human phase I study of ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in subjects with open-angle glaucoma undergoing glaucoma filtration surgery. [O] . Norbert Pfeiffer, Bogomil Voykov, Giulia Renieri, 2017

机译：IsTH0036的第一阶段研究，IsTH0036是一种选择性靶向转化生长因子β2（TGF-β2）的反义寡核苷酸，用于接受青光眼滤过手术的开角型青光眼患者。
8. Expression of Transforming Growth Factor-Beta (TGF-Beta) in Prostate Cancer Progression [R] . Lee, C. 2003

机译：转化生长因子-β（TGF-β）在前列腺癌进展中的表达

Extended preclinical ocular biodistribution and pharmacodynamic profile of ISTH0036, an antisense oligonucleotide targeting transforming growth factor beta 2 (TGF-beta 2) for the treatment of ophthalmic diseases

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