Crystal Structure of Ionic Compound Between Antiviral Drug Acyclovir and Complex Ruthenate(II)

摘要

Novel compound,(acvH)[trans-RuCl4(dmso-0)NO](1)(dmso-O is dimethylsulfoxide coordinated through oxygen atom),was isolated from the reaction between antiviral drug acyclovir(acv)and ruthenium precursor((dmso)2H)[trans-RuCl4(dmso-0)NO](2).Crystal structure revealed that compound 1 is of ionic type,containing N(7)protonated acyclovir(acvH)which is not coordinated to the metal center.There is a distorted octahedral coordination around ruthe-nium(II)center in 1.Four chlorido ligands are lying in a plane,whereas dmso molecule and nitrosyl group(coordinated through nitrogen atom)are bonded in trans axial positions.In spite the fact that acv(which is nucleoside analogue)is protonated,a glycoside bond between N(9)and side chain remained intact.