Syntheses and Cytotoxicity of Pt(II) Complexes with Acyclovir

摘要

Acyclovir is an antiviral drug which acts against the viruses,including Herpes simplex 1 and 2 and Varicella-zoster.The novel cis-[PtI_2(3-Hmpy)_2](3-Hmpy = 3-hydroxymethylpyridine)(2) and the water-soluble cationic Pt(II) complexes with acyclovir (acv,(9-[(2-hydroxyetoxy)methyl]guanine)),cis-[Pt(acv-N_7)_2(NH_3)_2]Cl_2 centre dot 2H_2O (1) and cis-[Pt(acv-N_7)_2(3-Hmpy)_2](NO_3)_2 (3),have been prepared and characterized by multinuclear NMR spectroscopy.The results of cytotoxicity assay of 1,3 and cis-[PtCl_2(NH_3)_2] (cisplatin,cDDP) performed in malignant melanoma B16 cells in vitro provide evidence that complex 1 and 3 are less cytotoxic compared to cisplatin.In vivo experiments performed on the same malignant melanoma B16 cells,grown as subcutaneous tumours,demonstrated that antitumour effectiveness of 1 was comparable to that of cisplatin.