Welche Eigenschaften von Nanopartikeln bestimmen deren Aufnahme in Zellen?

摘要

Even minor discrepancies in the physicochemical properties of nanoparticles (NP) contribute significantly to their interaction with the living cells. The effect of polymer type and surface coating on cellular uptake of polylactide (PLLA) and polystyrene (PS) NP was studied in C6 from rat and human U251 MG cell lines. In C6 cells, NP covered with anionic surfactant show better uptake compared to NP covered with Tween 80. In human cells, the presence of Tween 80 enhances the uptake of PLLA NP, but inhibits the internalization of PS ones.