Molecular cell biology: Proteostasis - Chaperone as companion from the cradle to the grave [Molekulare Zellbiologie Proteostase - Chaperone als Begleiter von der Wiege bis zum Grabe]

摘要

Molecular chaperones are often described as folding factors. However, chaperone-assisted degradation is also essential for maintaining the proteome. Impaired degradation contributes to the development of cancer, muscle weakness and neurodegeneration.