Posttranslational modifications. Oxidation of cysteines: More than an artifact of protein analysis [Oxidation von Cysteinen: mehr als ein Artefakt der Proteinanalytik]

摘要

Over the last years redox regulated proteins emerged to influence several key functions of the cell and became relevant switches. It appears that cysteine residues are important players in this game, as the thiol - the functional group of cysteines - can undergo a wide range of oxidative modifications and can be seen as a functional posttranslational modification. Recently several advances were made in identifying and quantifying oxidatively modified cysteines using protein analytical and mass spectrometric methods.