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Association between exposure to rotating night shift versus day shift using levels of 6-sulfatoxymelatonin and cortisol and other sex hormones in women

机译:妇女中使用6-硫氧嘧啶褪黑激素和皮质醇及其他性激素的水平导致的轮班夜班暴露与白班暴露之间的关联

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The present study aims to compare 6-sulfatoxymelatonin (aMT6s) secretion patterns and levels of cortisol and sex hormones (estradiol, progesterone, DHEA, DHEAS, and testosterone) among rotating night-shift workers and day-shift workers. We performed a cross-sectional study in Cantabria (northern Spain) including 136 women (73 day-shift workers and 63 rotating night-shift workers). Blood and urine samples were obtained after two consecutive working days. Differences in means were estimated using ANCOVA, stratified by menopausal status, ovulation phase, and adjusted for season, age, body mass index, consumption of cigarettes in the last 24 h. aMT6s circadian rhythm was analyzed using the cosinor analysis. The present study showed that rotating night-shift workers had lower excretion of aMT6s than day-shift workers (mesor = 50.26 ng aMT6s/mg creatinine in women with rotating night shift versus 88.79 ng aMT6s/mg creatinine in women with day shift), lower fluctuation (amplitude = 45.24 ng aMT6s/mg creatinine in rotating night-shift workers versus 79.71 ng aMT6s/mg creatinine in day-shift workers), and a later acrophase (aMT6s peak time: 08:31 in rotating night-shift workers versus 07:13 h in day-shift workers). Additionally, women with rotating night shift had higher estradiol and progesterone levels, compared to day workers, especially in the follicular phase on the menstrual cycle.
机译:本研究的目的是比较轮班的夜班工人和日班工人的6-巯基氧基褪黑激素(aMT6s)分泌模式以及皮质醇和性激素(雌二醇,孕酮,DHEA,DHEAS和睾丸激素)的水平。我们在坎塔布里亚(西班牙北部)进行了横断面研究,其中包括136名妇女(73名日班工人和63名夜班工人)。连续两个工作日后采集血液和尿液样本。使用ANCOVA估算均值差异,并按更年期状态,排卵期分层,并根据季节,年龄,体重指数,最近24小时的卷烟消费量进行调整。使用余弦分析法分析了aMT6s的昼夜节律。本研究表明,轮班的夜班工人比白班的工人的aMT6s排泄量低(轮班夜班的妇女的中值= 50.26 ng aMT6s / mg肌酐,而白班的妇女为88.79 ng aMT6s / mg肌酐),较低波动(轮班的夜班工人的幅度= 45.24 ng aMT6s / mg肌酐,而白班的工人为79.71 ng aMT6s / mg肌酐)和后来的顶峰期(轮班的夜班工人的aMT6s高峰时间:08:31与07 :13个小时的白班工人)。此外,与日间工作的人相比,夜班轮换的妇女的雌二醇和孕酮水平更高,尤其是在月经周期的卵泡期。

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