Predictors of All-Cause Mortality in Patients with Stable COPD: Medical Co-morbid Conditions or High Depressive Symptoms

摘要

Co-morbid conditions are frequently found in patients with COPD, We evaluate the association of co-morbidities with mortality, in stable COPD. 224 patients, mean age 61.2 (±10,00), 48.2% female, mean FEV, 1.1 (±0.5) filers, median follow-up time 4.2 years, participated. Medical co-morbidities were scored according to the Chanson Co-morbidity Index (CGI). Depressive symptoms were assessed with the Hospital Anxiety and Depression Scale (BADS) and Symptom Checklist-go (SCL-90), The Cox proportional hazard model was used for survival analyses. !n our sample. 79% of all patients have a no-morbid medical condition or high depressive symptoms. During follow-up 51% of ail patients died, and those with heart failure have the highest mortality rate (75%). Age, fat-free mass and exercise capacity were predictive factors, contrary to GCI-seores and high depressive symptoms, An unadjusted association between heart failure and survival was found. Although the presence of co-morbidities, using the CCl-score, is not related to survival, heart failure seems to have a detrimental effect on survival. Higher age and lower exercise capacity or fat-free mass predict mortality.