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Studying the Effect of Imipramine on Morphometric and Histopathological Changes of Ovary in Adult Female Rat

机译:研究丙咪嗪对成年雌性大鼠卵巢形态学和组织病理学变化的影响

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Purpose and background: the aim of this study was investigating intraperitoneal injection of different doses of Imipramine on the number of follicles in the adult female rat. Infertility that occurs as a result of taking drugs is an important clinicalissue. Rate of infertility that has been reported as a result of taking antidepressant drugs is 60%, in spite of its popularity a slight amount of studies has been formed to clarify the mechanism of action on these drugs, this study has written about Imipramine. forty female wistar 180 ± 20 g, selected and distributed them into groups experimental 1,2, and 3. And they injected 6.25,12.5, and 25 mg/kg bodyweight Imipramine respectively for 4 weeks, control group receives nothing, and sham group receives distilled water, at the end the samples of ovary tissue were taken to the laboratory for slice preparation, and slides of different parts of ovary made us available to count total number of follicles in each ovary. Results showed that this drug has noeffect on bodyweight, ovary and primitive, secondary, graffian and atretic follicles. Different doses of imipramine, number of primary follicles, also 25 mg/kg dose of this drug has caused Corpusluteum to decrease.
机译:目的和背景:本研究的目的是研究腹腔内注射不同剂量的丙咪嗪对成年雌性大鼠卵泡数量的影响。服用药物引起的不孕症是重要的临床问题。服用抗抑郁药导致的不育症报道率为60%,尽管其流行,但仍进行了少量研究以阐明对这些药物的作用机理。四十只雌性wistar 180±20 g,选择并分配给实验1、2和3组。她们分别注射6.25、12.5和25 mg / kg体重的丙咪嗪4周,对照组不予治疗,假手术组给予蒸馏水,最后将卵巢组织样品送至实验室进行切片制备,并且卵巢不同部分的载玻片使我们能够计算每个卵巢中的卵泡总数。结果表明,该药物对体重,卵巢和原始,继发性,涂鸦性和闭锁性卵泡无影响。不同剂量的丙咪嗪,主要卵泡的数量以及该药的25 mg / kg剂量也导致Corpusluteum减少。

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