Anticonvulsant Activity of Glaucium vitellinum Boiss & Buhse

摘要

The anticonvulsant activities of Glauciximvitellinum extract and alkaloid sub-fraction were assessed in pentylenetetrazole (PTZ)-induced convulsion and maximal electroshock test (MEST) in mice, with Diazepam as standard drug. While mechanistic studieswere conducted using flumazenil, a GABAA-benzodiazepine receptorcomplex site antagonist.The extract and the alkaloid sub-fractionproduced protectionagainst convulsion atlOO, 200, 400 mg/kg and 50 mg/kg respectively compared with protection with benzodiazepine.The mean onset and percentage protection against convulsion in extract/sub-fraction-treated mice werereduced by flumazenil. We also showed that G. vitellinum extract (200 mg/kg) exhibited inhibition of the tonic convulsion induced by MES and decreased mortality rate.These results suggest that G. it ('IIimini possesses biologically active constituent(s) mainly belong to isoquinoline alkaloid group that haveanticonvulsant activity which supports the ethnomedicinal claims of the use of the plant in the management of seizure.