Proteomic Comparison of Damaged Sciatic Nerves of a Newt, Triturus karelinii (Amphibia: Urodela) During the First 24th Hour of Regeneration Period

摘要

Background: Regenerative capacity of urodele amphibians, in which they have through their lifetime, is unique among vertebrates. The regeneration period and the underlying mechanisms have become an important field with the technical developments in molecular biology research. Because of the structure of peripheral nerves, changes such as protein destruction, local protein synthesis and post-translational modifications occur independently from the cell body after the first few hours of peripheral nerve damage. All the changes during this period are based on proteom level, which makes detailed proteomics studies favorable for understanding the regeneration mechanism in peripheral nerves.