Weekly Paclitaxel投与と放射線療法の併用が有用であった進行再発乳癌の2例

摘要

Paclitaxel（TXL）のweekly投与と放射線照射の併用が有用であった2例を経験したので報告する。投与法は，TXL 80mg/m2 short premedicationを用い，約1時間で点滴投与した。 症例1は，50歳，女性。 乳癌脳転移加療後，右中葉の無気肺が出現し，肺門，縦隔，鎖骨上帯リンパ節転移と診断した。 Weekly TXL投与と縦隔，鎖骨上窩の放射線照射の併用を行い，加療後1か月で肺門，縦隔リンパ節転移は消失した。 症例2は，31歳，女性。 肺，胸膜，骨，眼窩部転移を伴う進行乳癌であり，Weekly TXL投与と眼窩部の放射線照射の併用を行った。加療後1か月で肺，胸膜転移は消失し，眼窩部転移は約75％縮小しPRとなった。 2例とも白血球減少やその他の重篤な副作用は認められなかった。 We report two cases in which weekly paclitaxel (TXL) administration and concurrent radiation was effective for metastatic breast cancer, TXL (80mg/m2) was infused over 1 hour after short premedication, Case 1: A 50-year-old woman was found to have atelectasis of the middle lobe after treatment for brain metastasis,. She was diagnosed with hilar, mediastinal and supraclavicular lymph nodes metastases. She received weekly TXL administration and concurrent radiation to the mediastinum and supraclavicular fossa,. The metastatic lymph nodes had disappeared one month after the treatment, Case 2: A 31-year-old woman was diagnosed with advanced breast cancer with lung, pleural, bone and orbital metastases, She received weekly TXL administration and concurrent radiation to the orbit. The lung and pleural metastases had disappeared and the orbital metastasis was decreased by 75% one month after the treatment, and the case was assessed as a partial response, Leukopenia and other major adverse effects were not observed in either of the two cases.