A randomized, double-blind, placebo-controlled trial of anticholinergic medication for nonresponders to desmopressin for monosymptomatic nocturnal enuresis.

摘要

Austin PF, Ferguson G, Yan Y, et al.: Combination therapy with desmopressin and an anticholinergic medication for nonresponders to desmopressin for mono-symptomatic nocturnal enuresis: a randomized, double-blind, placebo-controlled trial. Pediatrics 2008, 122:1027-1032.This trial represents a randomized, double-blind, placebo-controlled trial of combination therapy with desmopressin and an anticholinergic medication for nonresponders to desmopressin for mono symptomatic nocturnal enuresis. In this study, 34 patients with primary nocturnal enuresis (and no lower urinary tract symptoms or bowel dysfunction), refractory to maximal desmopressin therapy, were randomized to placebo versus extended-release anticholinergic medication for 1 month of therapy.