Phosphorus-nitrogen compounds. part 38. Syntheses, characterizations, cytotoxic, antituberculosis and antimicrobial activities and DNA interactions of spirocyclotetraphosphazenes with bis-ferrocenyl pendant arms

摘要

AbstractThe reactions of N4P4Cl8(1), with two equimolar amounts ofN-(1-ferrocenylmethyl)-N-methyl-propylenediamine gave the monoferrocenyl-spiro (as a byproduct), bisferrocenyl-2-trans-6-dispiro (2) and bisferrocenyl-2-cis-6-dispiro (3) cyclotetraphosphazenes. The 2-trans-6-dispiro (2) was reacted with excess monoamines to produce the tetraamino products (2a-2d). The one equimolar amount of the diamines and dialkoxides with2afforded the mono-diamino (2eand2f) and mono-dialkoxy (2gand2h) cyclotetraphosphazenes. Whereas, excess diamines and dialkoxides with2produced the bis-diamino (2iand2j) and bis-dialkoxy (2kand2l) bisferrocenyl-2-trans-6-dispirocyclotetraphosphazenes. The structures of the compounds were verified by elemental analyses, ESI-MS, FTIR, HSQC, HMBC,1H,13C, and31P NMR techniques. The molecular structures of2and2bwere established by X-ray crystallography. Compounds2eand2fhave two stereogenic P-atoms. Additionally, the structures of2i-2lcontaining tetraspiro rings in the skeletons