Organometallic ruthenium(II) complexes containing NS donor Schiff bases: Synthesis, structure, electrochemistry, DNA/BSA binding, DNA cleavage, radical scavenging and antibacterial activities

摘要

AbstractFour new cyclopentadienylruthenium(II)-acetophenone-4(N)-substituted thiosemi-carbazone complexes, with the general formula [Ru(?5-C5H5)(H-Aptsc)PPh3].Cl (1), [Ru(?5-C5H5)(H-Apmtsc)PPh3].Cl (2), [Ru(?5-C5H5)(H-Ap-etsc)PPh3].Cl (3) and [Ru(?5-C5H5)(H-Ap-ptsc)PPh3].Cl (4) were synthesised and characterised (1H NMR,13C NMR, IR and electronic spectroscopy). The molecular structure of representative complexes2and3was confirmed by single crystal X-Ray diffraction technique. The binding ability of complexes (1–4) to calf-thymus DNA (CT DNA) and Bovine Serum Albumin (BSA) has been explored by absorption and emission titration methods. Based on the observations, an electrostatic and an intercalative binding mode have been proposed for the complexes with CT-DNA. The BSA protein binding studies have been monitored by quenching of tryptophan and tyrosine residues in the presence of complexes and static type of quenching mechanism has been proposed.In?vitrofree radical scavengin