Synthesis, characterization and biological applications of substituted pyrazolone core based platinum(II) organometallic compounds

摘要

AbstractNew series of organometallic platinum(II) compounds(I-VI)containing the 2-phenyl-5-methyl pyrazole-3-one derivatives ligands (L1-L6) were synthesized and characterized by spectroscopic and physicochemical techniques. The synthesized compounds were screen for theirin?vitroantibacterial activity against two Gram(+ve)and three Gram(?ve)bacterial species.In?vitrocytotoxicity against brine shrimp lethality bioassay andin?vitrocellular level cytotoxicity againstS.?pombecells were carried out for the synthesized compounds. Complexes (I-VI) exhibit excellent cytotoxicity as compared to ligands (L1-L6). DNA interaction and DNA cleavage study of the synthesized ligands and complexes were carried out using absorption titration spectroscopy, fluorescence quenching analysis, viscosity measurements, molecular docking study and agarose gel electrophoresis. The interactions of compounds towards herring sperm DNA (HS-DNA) was examined. The binding constant (Kb), Stern-Volmer quenching constant (Ksv) and associative binding constant (Ka) of the synthesized ligands and complexes were observed in the range of 0.138–5.580?×?105?M?1, 1.1?×?102to 7.0?×?10