A Multicenter, Open-Label, Randomized Phase II Controlled Study of rh-Endostatin (Endostar) in Combination with Chemotherapy in Previously Untreated Extensive-Stage Small-Cell Lung Cancer

Lu Shun; Li Lu; Luo Yi; Zhang Li; Wu Gang; Chen Zhiwei; Huang Cheng; Guo Shuliang; Zhang Yiping; Song Xiangqun; Yu Yongfeng; Zhou Caicun; Li Wei; Liao Meilin; Li Baolan; Xu Liyan; Chen Ping; Hu Chunhong; Hu Chengping

首页> 外文期刊>Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer >A Multicenter, Open-Label, Randomized Phase II Controlled Study of rh-Endostatin (Endostar) in Combination with Chemotherapy in Previously Untreated Extensive-Stage Small-Cell Lung Cancer

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A Multicenter, Open-Label, Randomized Phase II Controlled Study of rh-Endostatin (Endostar) in Combination with Chemotherapy in Previously Untreated Extensive-Stage Small-Cell Lung Cancer

机译：rh-nodostatin（endostar）在先前未处理的广泛阶段小细胞肺癌中组合的多中心，开放标签，随机期II对照研究

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摘要

Background: Based on promising efficacy in a single-arm study, a randomized phase II trial was designed to compare the efficacy and safety of adding rh-endostatin (Endostar) to first-line standard etoposide and carboplatin (EC) chemotherapy for treatment of extensive-stage small-cell lung cancer.

机译：背景：基于单臂研究中有希望的疗效，旨在比较将Rh-nodostatin（endostar）添加到一线标准依托泊苷和卡铂（EC）化疗的疗效和安全性以进行广泛的疗效 - 细胞肺癌。

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来源
《Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer》 |2015年第1期|共6页
作者
Lu Shun; Li Lu; Luo Yi; Zhang Li; Wu Gang; Chen Zhiwei; Huang Cheng; Guo Shuliang; Zhang Yiping; Song Xiangqun; Yu Yongfeng; Zhou Caicun; Li Wei; Liao Meilin; Li Baolan; Xu Liyan; Chen Ping; Hu Chunhong; Hu Chengping;
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作者单位

Shanghai Jiao Tong Univ Chest Hosp Shanghai Lung Canc Ctr Dept Oncol Shanghai 200030 Peoples R;

Sichuan Univ West China Hosp Dept Thorac Canc Ctr Canc Chengdu 610064 Peoples R China;

Hunan Prov Tumor Hosp Dept Med Oncol Changsha Hunan Peoples R China;

Sun Yat Sen Univ Ctr Canc Dept Med Oncol Guangzhou 510275 Guangdong Peoples R China;

Huazhong Univ Sci &

Technol Tongji Med Coll Canc Ctr Union Hosp Wuhan 430074 Peoples R China;

Shanghai Jiao Tong Univ Chest Hosp Shanghai Lung Canc Ctr Dept Oncol Shanghai 200030 Peoples R;

Fujian Med Univ Educ Hosp Fujian Prov Tumor Hosp Dept Med Oncol Fuzhou Peoples R China;

Chongqing Univ Med Sci Affiliated Hosp 1 Dept Resp Med Chongqing Peoples R China;

Zhejiang Canc Hosp Chemotherapy Ctr Hangzhou Zhejiang Peoples R China;

Guangxi Med Univ Affiliated Tumor Hosp Dept Chemotherapy Guangxi Peoples R China;

Shanghai Jiao Tong Univ Chest Hosp Shanghai Lung Canc Ctr Dept Oncol Shanghai 200030 Peoples R;

Tongji Univ Shanghai Pulm Hosp Dept Oncol Shanghai 200092 Peoples R China;

Jilin Univ Univ Hosp 1 Ctr Canc Changchun 130023 Peoples R China;

Shanghai Jiao Tong Univ Chest Hosp Shanghai Lung Canc Ctr Dept Oncol Shanghai 200030 Peoples R;

Beijing Chest Hosp Dept Gen Beijing Peoples R China;

Beijing Chest Hosp Dept Gen Beijing Peoples R China;

Central South Univ Xiangya Hosp 2 Dept Oncol Changsha Hunan Peoples R China;

Central South Univ Xiangya Hosp 2 Dept Oncol Changsha Hunan Peoples R China;

Cent Southern Univ Xiang Ya Hosp Dept Resp Dis Changsha Hunan Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Etoposide; Carboplatin; Rh-endostatin; Extensive-stage small-cell lung cancer; Survival;

机译：依托泊苷;卡铂;rh-nodostatin;广泛阶段的小细胞肺癌;生存;

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专利

1. A Multicenter, Open-Label, Randomized Phase II Controlled Study of rh-Endostatin (Endostar) in Combination with Chemotherapy in Previously Untreated Extensive-Stage Small-Cell Lung Cancer [J] . Lu Shun, Li Lu, Luo Yi, Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer . 2015,第1期

机译：rh-nodostatin（endostar）在先前未处理的广泛阶段小细胞肺癌中组合的多中心，开放标签，随机期II对照研究
2. Randomized phase II study of bevacizumab in combination with chemotherapy in previously untreated extensive-stage small-cell lung cancer: results from the SALUTE trial. [J] . Spigel DR, Townley PM, Waterhouse DM, Journal of Clinical Oncology . 2011,第16期

机译：贝伐单抗联合化学疗法治疗先前未治疗的广泛期小细胞肺癌的随机II期研究：SALUTE试验的结果。
3. Chemotherapy With or Without Maintenance Sunitinib for Untreated Extensive-Stage Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase II Study-CALGB 30504 (Alliance) [J] . Ready Neal E., Pang Herbert H., Gu Lin, Journal of Clinical Oncology . 2015,第15期

机译：有或没有维持性舒尼替尼治疗未治疗的广泛期小细胞肺癌的化疗：一项随机，双盲，安慰剂对照的II期临床研究-CALGB 30504（联盟）
4. An open-label, multicenter, randomized,comparative, safety, efficacy, cycle control,and quality of life study of CTR 25, Alesse ,and Ortho Tri-Cyclen [C] . Victoria Davis, Brian Hauck, Sheila Dunn, World Congress on Fertility and Sterility . 2004

机译：开放标签，多中心，随机，比较，安全，疗效，循环控制和CTR 25，Alesse和Ortho Tri-Cyclen的生命研究
5. A Study of Erlotinib Monotherapy and in Combination with Pembrolizumab in Previously Untreated Stage I-IIIA Non-small Cell Lung Cancer [D] . Liu, Qiong. 2021

机译：Erlotinib单疗法和蛋白质在先前未处理阶段I-IIIA非小细胞肺癌中的研究
6. Chemotherapy With or Without Maintenance Sunitinib for Untreated Extensive-Stage Small-Cell Lung Cancer: A Randomized Double-Blind Placebo-Controlled Phase II Study—CALGB 30504 (Alliance) [O] . Neal E. Ready, Herbert H. Pang, Lin Gu, -1

机译：有或没有维持性舒尼替尼治疗未治疗的广泛期小细胞肺癌的化疗：一项随机双盲安慰剂对照的II期临床研究—CALGB 30504（联盟）
7. A Multicenter, Open-Label, Randomized Phase II Controlled Study of rh-Endostatin (Endostar) in Combination with Chemotherapy in Previously Untreated Extensive-Stage Small-Cell Lung Cancer [O] . Lu Shun, Li Lu, Luo Yi, 2015

机译：多中心，标签公开，随机II期rh-内皮抑素（Endostar）联合化学疗法治疗未经治疗的广泛期小细胞肺癌的随机对照研究

A Multicenter, Open-Label, Randomized Phase II Controlled Study of rh-Endostatin (Endostar) in Combination with Chemotherapy in Previously Untreated Extensive-Stage Small-Cell Lung Cancer

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