Long-Term Sirolimus for Primary Immunosuppression in Heart Transplant Recipients

Asleh Rabea; Briasoulis Alexandros; Kremers Walter K.; Adigun Rosalyn; Boilson Barry A.; Pereira Naveen L.; Edwards Brooks S.; Clavell Alfredo L.; Schirger John A.; Rodeheffer Richard J.; Frantz Robert P.; Joyce Lyle D.; Maltais Simon; Stulak John M.; Daly Richard C.; Tilford Jonella; Choi Woong-Gil; Lerman Amir; Kushwaha Sudhir S.

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Long-Term Sirolimus for Primary Immunosuppression in Heart Transplant Recipients

机译：心脏移植受者的主要免疫抑制的长期西罗司

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BACKGROUND Small studies have reported superiority of sirolimus (SRL) over calcineurin inhibitor (CNI) in mitigating cardiac allograft vascutopathy (CAV) after heart transplantation (HT). However, data on the tong-term effect on CAV progression and clinical outcomes are tacking.

机译：背景技术小型研究报告了在心脏移植（HT）后减轻心脏同种异体移植血管神经病症（CAV）中的钙碱抑制剂（CNI）的Sirolimus（SRL）的优越性。然而，关于对CAV进展和临床结果的桐术效应的数据正在加粘。

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《Journal of the American College of Cardiology》 |2018年第6期|共15页
作者
Asleh Rabea; Briasoulis Alexandros; Kremers Walter K.; Adigun Rosalyn; Boilson Barry A.; Pereira Naveen L.; Edwards Brooks S.; Clavell Alfredo L.; Schirger John A.; Rodeheffer Richard J.; Frantz Robert P.; Joyce Lyle D.; Maltais Simon; Stulak John M.; Daly Richard C.; Tilford Jonella; Choi Woong-Gil; Lerman Amir; Kushwaha Sudhir S.;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
cardiac allograft vasculopathy; coronary intravascular ultrasound; heart transplantation; immunosuppression;

机译：心脏异种移植血管病;冠状动脉血管内超声;心脏移植;免疫抑制;

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专利

1. Long-Term Sirolimus for Primary Immunosuppression in Heart Transplant Recipients [J] . Asleh Rabea, Briasoulis Alexandros, Kremers Walter K., Journal of the American College of Cardiology . 2018,第6期

机译：心脏移植受者的主要免疫抑制的长期西罗司
2. Long-Term Sirolimus for Primary Immunosuppression and Incidence of De Novo Malignancy Following Heart Transplantation [J] . Asleh R., Li X., Alnsasra H., The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation . 2019,第4Suppla期

机译：用于初级免疫抑制和心脏移植后De Novo恶性肿瘤发病率的长期西罗司
3. Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial. [J] . Salgo R, Gossmann J, Schofer H, American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons . 2010,第6期

机译：在长期的肾移植受者中转用基于西罗莫司的免疫抑制：在一项前瞻性，随机，评估者盲目的对照临床试验中，降低（恶性肿瘤）和非黑色素瘤皮肤癌的发病率。
4. Noninvasive Strategy for Early Prediction of Transplant Coronary Arteriopathy and Timing of Coronary Angiographies in Heart Transplant Recipients [C] . M. Dartdel, F. Knollmann, E. Wcllnhofer International Congress on Coronary Artery Disease . 2003

机译：心脏移植受者的移植冠状动脉动脉病变及冠状动脉血管造影时期的非侵入性策略
5. Mycophenolic acid versus azathioprine in primary immunosuppression for kidney transplant recipients - Systematic review, meta-analysis, and meta-regression. [D] . Wagner, Martin. 2009

机译：麦考酚酸与硫唑嘌呤在肾移植受者初次免疫抑制中的作用-系统评价，荟萃分析和荟萃回归。
6. A Prospective Randomised Paired Trial of Sirolimus versus Tacrolimus as Primary Immunosuppression following Non-Heart Beating Donor Kidney Transplantation [O] . John Asher, Nikhil Vasdev, Hugh Wyrley-Birch, 2014

机译：西罗莫司和他克莫司作为非心脏跳动捐赠者肾脏移植后主要免疫抑制的前瞻性随机配对试验。
7. Sirolimus-based immunosuppression improves outcomes in liver transplantation recipients with hepatocellular carcinoma beyond the Hangzhou criteria [O] . Sunbin Ling, Tingting Feng, Qifan Zhan, 2020

机译：基于西罗司的免疫抑制改善肝移植受者的结果，肝细胞癌超出杭州标准

Long-Term Sirolimus for Primary Immunosuppression in Heart Transplant Recipients

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