Coronary Physiology During Exercise and Vasodilation in the Healthy Heart and in Severe Aortic Stenosis

Lumley Matthew; Williams Rupert; Asrress Kaleab N.; Arri Satpal; Briceno Natalia; Ellis Howard; Rajani Ronak; Siebes Maria; Piek Jan J.; Clapp Brian; Redwood Simon R.; Marber Michael S.; Chambers John B.; Perera Divaka

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Coronary Physiology During Exercise and Vasodilation in the Healthy Heart and in Severe Aortic Stenosis

机译：在健康心脏和严重主动脉狭窄中运动和血管血管血管血管血管狭窄期间的冠状动脉生理

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摘要

BACKGROUND Severe aortic stenosis (AS) can manifest as exertional angina even in the presence of unobstructed coronary arteries.

机译：背景技术即使在不受阻碍的冠状动脉的存在下也可以表现为具有抵押血管的。

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来源
《Journal of the American College of Cardiology》 |2016年第7期|共10页
作者
Lumley Matthew; Williams Rupert; Asrress Kaleab N.; Arri Satpal; Briceno Natalia; Ellis Howard; Rajani Ronak; Siebes Maria; Piek Jan J.; Clapp Brian; Redwood Simon R.; Marber Michael S.; Chambers John B.; Perera Divaka;
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作者单位

Kings Coll London British Heart Fdn Ctr Excellence St Thomas Hosp Campus London England;

Kings Coll London British Heart Fdn Ctr Excellence St Thomas Hosp Campus London England;

Kings Coll London British Heart Fdn Ctr Excellence St Thomas Hosp Campus London England;

Kings Coll London British Heart Fdn Ctr Excellence St Thomas Hosp Campus London England;

Kings Coll London British Heart Fdn Ctr Excellence St Thomas Hosp Campus London England;

Kings Coll London British Heart Fdn Ctr Excellence St Thomas Hosp Campus London England;

Guys &

St Thomas NHS Fdn Trust Dept Cardiol London England;

Univ Amsterdam Acad Med Ctr Dept Biomed Engn Amsterdam Netherlands;

Univ Amsterdam Acad Med Ctr Heart Ctr Amsterdam Netherlands;

Guys &

St Thomas NHS Fdn Trust Dept Cardiol London England;

Kings Coll London British Heart Fdn Ctr Excellence St Thomas Hosp Campus London England;

Kings Coll London British Heart Fdn Ctr Excellence St Thomas Hosp Campus London England;

Guys &

St Thomas NHS Fdn Trust Dept Cardiol London England;

Kings Coll London British Heart Fdn Ctr Excellence St Thomas Hosp Campus London England;

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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
coronary blood flow; microvascular resistance; velocity; wave intensity analysis;

机译：冠状动脉血流;微血管抵抗;速度;波浪强度分析;

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专利

1. Coronary Physiology During Exercise and Vasodilation in the Healthy Heart and in Severe Aortic Stenosis [J] . Lumley Matthew, Williams Rupert, Asrress Kaleab N., Journal of the American College of Cardiology . 2016,第7期

机译：在健康心脏和严重主动脉狭窄中运动和血管血管血管血管血管狭窄期间的冠状动脉生理
2. Adaptations to Coronary Physiology in a Patient With Severe Aortic Stenosis and Complete Heart Block Undergoing Transcatheter Aortic Valve Replacement [J] . Michail Michael, Asrress Kaleab N., Cameron James D., JACC. Cardiovascular interventions . 2019,第7期

机译：在具有严重主动脉狭窄的患者中对冠状动脉生理的适应和经历过度传道管主动脉瓣置换的完全心阻滞
3. Physiologic evaluation of coronary lesions using instantaneous wave-free ratio (iFR) in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation [J] . Scarsini Roberto, Pesarini Gabriele, Zivelonghi Carlo, EuroIntervention: journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology . 2018,第13期

机译：患有瞬间波动瓣膜瓣膜植入术患者瞬时波动率（IFR）的冠状动脉病变的生理学评价
4. Aortic Valve Replacement or Heart Transplantation in Patients with Aortic Stenosis and Severe Left Ventricular Dysfunction [C] . Czer L.S.C., Gol S., Soukiasian H., International Congress on Coronary Artery Disease. . 2013

机译：主动脉狭窄和严重左心室功能障碍患者的主动脉瓣替代或心脏移植
5. Systolic Coronary Flow Reversal and Abnormal Diastolic Flow Patterns in Patients With Aortic Stenosis : Assessment With an Intracoronary Doppler Catheter [D] . Yoshikawa, Junichi 1994

机译：主动脉瓣狭窄患者的收缩期冠状动脉血流逆转和舒张期血流异常：用冠状动脉内多普勒导管评估
6. Endovascular repair of severe aortic coarctation transcatheter aortic valve replacement for severe aortic stenosis and percutaneous coronary intervention in an elderly patient with long term follow-up [O] . Raneem Fallatah, Abdelfatah Elasfar, Osama Amoudi, 2018

机译：老年患者的长期随访进行严重主动脉缩窄的血管内修复经导管主动脉瓣置换以治疗严重的主动脉瓣狭窄以及经皮冠状动脉介入治疗
7. P981Lvot area measurement using gated ct data reclassifies aortic stenosis severity as graded by echocardiographyP982Paradoxical low-flow low-gradient aortic stenosis: an intermediate state between moderate and severe aortic stenosis?P983Can rheumatic significant mitral stenosis be a cause of paradoxical low gradient, low flow, in patients with severe aortic stenosis? an echocardiographic and outcome studyP984Clinical and hemodynamic comparison of isolated versus combined aortic and mitral stenosisP985Echocardiographic end-diastolic velocity in the proximal descending aorta should be interpreted with caution when the ascending aorta is dilated: insights from cardiovascular magnetic resonanceP987Prevalence of atrial mitral regurgitation in patients with severe mitral regurgitationP988Role of 2D/3D echocardiography in the risk stratification of endocardial lead-related tricuspid regurgitation: a single-centre study among?241 patientsP989When TEE is needed in patients with staphylococcus aureus bacteremia for the assessment of risk profile of infective endocarditis?P990Appropriateness criteria to echocardiograms for suspected infective endocarditis: experience of a tertiary referral centerP991Independent predictors of outcome in infective endocarditisP992The role of transesophageal cardiography in clinical course and prognosis of complicated infective endocarditis in critically ill patients: our 15 years experienceP993Left bundle branch block atypical pattern as a prognostic determinant in patients taken to TAVIP994Efficacy of long-term ivabradine therapy in severe systolic chronic heart failure patients with and without type 2 diabetes mellitusP995Relations between left ventricular reverse remodeling and serum markers of extracellular matrix fibrosis in dilated cardiomyopathyP996The healthy left ventricle accommodates an increasing vortex formation time for volume transfer in diastolic filling :Implications for heart failureP997Evolutionary changes of pulmonary artery pressure after left ventricular assist device implantP998Functional correlates and prognostic value of coronary flow velocity reserve by vasodilator stress echocardiography in hypertrophic cardiomyopathyP999Quantification of myocardial performance in patients with non-obstructive versus latent-obstructive hypertrophic cardiomyopathyP1000Lifelong arrhythmic risk stratification in arrhythmogenic right ventricular cardiomyopathy: distribution of events and impact of periodical reassessmentP1001Impact of fibrosis visualized by CMR in vectorcardiogram recordings of patients with suspected arrhythmogenic cardiomyopathyP1002Determinants of the beneficial effect of aldosterone antagonism on exercise capacity in heart failure with reduced ejection fractionP1003Myocardial strain values in patients with acute myocarditis and preserved ejection fraction. A magnetic resonance feature tracking studyP1004Detection of subclinical left ventricular dysfunction by speckle tracking echocardiography in patients with myocarditis without prominent wall motion abnormalitiesP1005Aborted sudden cardiac death patients aged <50 years show only mild alterations on cardiac magnetic resonance imagingP1006Relationships between subepicardial and subendocardial longitudinal strain with late gadolinium enhancement in uncomplicated hypertensive patients [O] . L. Moderato, C. Di Nora, A. Soufiani, 2016

机译：P981LVOT区域测量使用门控CT数据重新分类主动脉狭窄的严重程度，以超声心动图7982分类为分类，如二醇的低流量低梯度主动脉狭窄：中度和严重主动脉狭窄之间的中间状态？P983CAN风湿显着二尖瓣狭窄是矛盾的低梯度，低流量的原因在严重主动脉狭窄的患者中？超声心动图和结合分离的主动脉和二尖瓣术和二尖瓣狭窄的血液动力学比较的超声心动图和血液动力学比较在近期下降主动脉中应当谨慎地解释升高的主动脉：从心血管磁共振的洞察中的心血管磁共振PREValence在严重的患者中的洞察中解释二尖瓣regurgitationP988 rool 2D / 3D超声心动图在内膜内铅相关三尖瓣反流的风险分层：241例患者中的单一学习，在葡萄球菌的患者中需要TEE，用于评估感染性心内炎的风险概况？P990姑息度标准怀疑感染心内膜炎的超声心动图：第三节推荐中心的经验，感染endocardisp992在感染性Endocardisap999中的临床过程中的作用和复杂感染的预后的作用生病患者的心内膜炎：我们的15年经验训练束分支块的非典型模式作为患者的预后决定因素，以TaviP994患者在严重的收缩期慢性心力衰竭患者中患者，无型糖尿病患者左心室反向重塑和血清基质纤维化的血清标志物在扩张心肌脑肿瘤中，健康的左心室容纳舒张填充中体积转移的增加的涡旋形成时间：对左心室辅助装置Implantp998函数相关和冠状动脉速率储备的肺动脉压的肺动脉压的影响。血管扩张器应力超声心动图在肥厚性心肌病型499中，非阻塞性患者心肌表现与潜在阻塞性肥厚性心肌病的患者患者患者患者患者血小板治疗1000Lifelong心律失常风险Strati心律病学右心室心肌病的发动机：CMR患者血管瘤术治疗患者血管动脉瘤患者血管诊断患者血管心目记录中CMR的纤维化术治疗的事件和影响患有急性心肌炎和保存的喷射分数。磁共振特征跟踪STOPYP1004DETTECTECTECTET通过突出壁运动患者的斑点左心室功能障碍的亚临床左心室功能障碍，没有突出的壁运动异常，P1005aborted突发的心脏死亡患者<50岁的突然性心脏死亡患者只显示心脏磁共振术中的轻度改变，钆和肾外腺纵向应变之间的心脏磁共振成像P1006相关性简单的高血压患者增强
8. Regional Coronary Blood Flow at Rest and during High Sustained +GZ in a Miniature Swine with Subclinical, Ischemic, Coronary Heart Disease Due to Coronary Stenosis. [R] . Laughlin, M. H., Witt, W. M., Burns, J. W., 1978

机译：冠状动脉狭窄导致亚临床，缺血性冠状动脉疾病的小型猪静息和高持续+ GZ区域冠状动脉血流量的变化。

Coronary Physiology During Exercise and Vasodilation in the Healthy Heart and in Severe Aortic Stenosis

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