A new quantification method for assessing plasma concentrations of pemetrexed and its polyglutamate metabolites

Stoop Marcel P.; Visser Sabine; van Dijk Evert; Aerts Joachim G. J. V.; Stricker Bruno H.; Luider Theo M.

首页> 外文期刊>Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis >A new quantification method for assessing plasma concentrations of pemetrexed and its polyglutamate metabolites

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A new quantification method for assessing plasma concentrations of pemetrexed and its polyglutamate metabolites

机译：一种评估血浆浓度的新磷络浓度及其聚谷氨酸代谢物的新定量方法

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摘要

Currently no quantification method exists for potentially therapeutically relevant polyglutamate metabolites of the drug pemetrexed which is used for the treatment of lung carcinoma patients.

机译：目前没有定量方法存在用于药物培养物的潜在治疗相关的聚谷氨酸代谢物，其用于治疗肺癌患者。

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来源
《Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis》 |2016年第null期|共8页
作者
Stoop Marcel P.; Visser Sabine; van Dijk Evert; Aerts Joachim G. J. V.; Stricker Bruno H.; Luider Theo M.;
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作者单位

ErasmusMC Dept Neurol Rotterdam Netherlands;

ErasmusMC Dept Pulm Dis Rotterdam Netherlands;

Pepscan BV Lelystad Netherlands;

ErasmusMC Dept Pulm Dis Rotterdam Netherlands;

ErasmusMC Dept Epidemiol Rotterdam Netherlands;

ErasmusMC Dept Neurol Rotterdam Netherlands;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Mass spectrometry; Pemetrexed; Plasma; Metabolites; Lung carcinoma;

机译：质谱;浇口;血浆;代谢物;肺癌;

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专利

1. A new quantification method for assessing plasma concentrations of pemetrexed and its polyglutamate metabolites [J] . Stoop Marcel P., Visser Sabine, van Dijk Evert, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2016,第Null期

机译：评估培美曲塞及其多谷氨酸代谢物血浆浓度的新定量方法
2. High and individually variable enzymatic activity precludes accurate determination of pemetrexed, methotrexate and their polyglutamate metabolite concentrations in plasma [J] . Marcel P. Stoop, Sabine Visser, Evert van Dijk, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2018,第期

机译：高且单独的变种酶活性排除了精确测定了戊酰基，甲氨蝶呤及其聚谷氨酸代谢物浓度的血浆
3. An improved HPLC-MS/MS method for simultaneous quantification of propranolol and its two phase I metabolites in plasma of infants with hemangioma and its application to a comparative study of plasma concentrations [J] . He Huan, Li Li, Zhao Libo, RSC Advances . 2018,第65期

机译：一种改进的HPLC-MS / MS方法，用于同时定量血浆血浆血浆血浆中血浆及其两阶段I代谢物及其在血浆浓度的比较研究中的应用
4. Quantification of Glargine and Its Metabolites in Human Plasma Using a Hybrid Immunoaffinity Purification and LC-MS/MS Methodology [C] . Li Sun, Yang Xu, Melanie Anderson, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：使用杂交免疫亲和纯化和LC-MS / MS方法定量人血浆中的狼吞虎胺及其代谢物
5. The quantification of metabolite concentrations in high resolution magic angle spinning (HR-MAS) NMR spectra from ex vivo prostate tissue. [D] . DiCamillo, Paul Allen. 2007

机译：来自离体前列腺组织的高分辨率魔角旋转（HR-MAS）NMR光谱中代谢物浓度的量化。
6. Ultra-Performance Liquid Chromatography Mass Spectrometry and Sensitive Bioassay Methods for Quantification of Posaconazole Plasma Concentrations after Oral Dosing [O] . Bertrand Rochat, Andres Pascual, Benoît Pesse, 2010

机译：口服给药后泊沙康唑血浆浓度的超高效液相色谱质谱和灵敏生物测定方法
7. An improved HPLC-MS/MS method for simultaneous quantification of propranolol and its two phase I metabolites in plasma of infants with hemangioma and its application to a comparative study of plasma concentrations [O] . Huan He, Li Li, Libo Zhao, 2018

机译：一种改进的HPLC-MS / MS方法，用于同时定量血浆血浆血浆血浆中血浆及其两阶段I代谢物及其在血浆浓度的比较研究中的应用

A new quantification method for assessing plasma concentrations of pemetrexed and its polyglutamate metabolites

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