Phase 1 Trial of Convection-Enhanced Delivery of Adeno-Associated Virus Encoding Glial Cell Line-Derived Neurotrophic Factor in Patients with Advanced Parkinson's Disease

Argersinger Davis Palmer; Lungu Codrin; Hammoud Dima; Herscovitch Peter; Ehrlich Debra; Scott Gretchen; Bankiewicz Krystof; Zaghloul Kareem; Hallett Mark; Lonser Russell; Heiss John

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Phase 1 Trial of Convection-Enhanced Delivery of Adeno-Associated Virus Encoding Glial Cell Line-Derived Neurotrophic Factor in Patients with Advanced Parkinson's Disease

机译：第1期对对流的试验增强腺相关病毒的增强递送编码患有先进帕金森病的患者胶质细胞系源性神经营养因子的腺相关病毒

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《Journal of neurosurgery.》 |2019年第1期|共1页
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Argersinger Davis Palmer; Lungu Codrin; Hammoud Dima; Herscovitch Peter; Ehrlich Debra; Scott Gretchen; Bankiewicz Krystof; Zaghloul Kareem; Hallett Mark; Lonser Russell; Heiss John;
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中图分类头部及神经外科学;
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1. Phase 1 Trial of Convection-Enhanced Delivery of Adeno-Associated Virus Encoding Glial Cell Line-Derived Neurotrophic Factor in Patients with Advanced Parkinson's Disease [J] . Argersinger Davis Palmer, Lungu Codrin, Hammoud Dima, Journal of neurosurgery. . 2019,第1期

机译：第1期对对流的试验增强腺相关病毒的增强递送编码患有先进帕金森病的患者胶质细胞系源性神经营养因子的腺相关病毒
2. Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease. [J] . Eslamboli A, Georgievska B, Ridley RM, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2005,第4期

机译：使用帕金森氏病的灵长类动物模型，使用重组腺相关病毒载体进行连续的低水平胶质细胞源性神经营养因子传递，可提供神经保护作用并诱导行为恢复。
3. Adeno-associated virus type 2 vector-mediated glial cell line-derived neurotrophic factor gene transfer induces neuroprotection and neuroregeneration in a ubiquitin-proteasome system impairment animal model of Parkinson's disease [J] . DuY., ZhangX., TaoQ., Neuro-degenerative diseases . 2013,第3期

机译：腺相关病毒2型载体介导的胶质细胞源性神经营养因子基因转移在帕金森氏病的泛素-蛋白酶体系统损伤动物模型中诱导神经保护和神经再生
4. Experimental study on Neural stem cell transplantation therapy modified by the gene of tyrosine hydroxylase and Glial cell line derived neurotrophic factor for Parkinson's disease rat model [C] . Haijuna Wang, Ye Luo, Ziying Liu, International Conference on Medical Engineering and Bioinformatics . 2015

机译：酪氨酸羟化酶基因改性神经干细胞移植治疗的实验研究帕金森氏病大鼠大鼠毒素的神经营养因子
5. I. Advanced Fluorescent False Neurotransmitters for the Study of Monoamine Transporter Activity and Synaptic Transmission. II. New Small-Molecule Inducers of Glial Cell Line-Derived Neurotrophic Factor (GDNF) from C6 Glioma Cells [D] . Karpowicz, Richard James 2013

机译：I.用于单胺转运蛋白活性和突触传递研究的高级荧光假神经递质。二。来自C6胶质瘤细胞的胶质细胞源性神经营养因子（GDNF）的新小分子诱导剂
6. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson’s disease in rats [O] . R. J. Mandel, S. K. Spratt, R. O. Snyder, 1997

机译：中脑注射重组腺相关病毒编码大鼠神经胶质细胞系神经营养因子在渐进性6-羟基多巴胺诱导的帕金森氏病退化模型中保护黑质神经元
7. Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease [O] . Eslamboli, A, Georgievska, Biljana, Ridley, R M, 2005

机译：使用重组腺相关病毒载体连续进行低水平神经胶质细胞系衍生的神经营养因子递送，在帕金森病的灵长类动物模型中提供神经保护并诱导行为恢复

Phase 1 Trial of Convection-Enhanced Delivery of Adeno-Associated Virus Encoding Glial Cell Line-Derived Neurotrophic Factor in Patients with Advanced Parkinson's Disease

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