Large scale production of oxytetracyclin using Streptomyces varsovances

摘要

Oxytetracyclin production by Streptomyces varsovances was done using sweet potato mash medium. Important process parameters like optimum pH .temperature, tip speed and Kla value for the antibiotic production was determined. Extraction of oxytetracyclin was carried out using boron tetrafluoride, extracted antibiotic was estimated using bioassay and HPLC. New production method was effective and gave 25% more yield as compared to traditional methods, extraction method is promising for large scale production.