Antihyperlipidemic activity of methanolic extract of Lagenaha siceraria

摘要

The present study is designed to evaluate the effect of methanolic extracts of Lagenaria siceraria on lipid profiles in Triton X-100 induced hyperlipidemia in male wistar rats. The fruit juice was obtained by crushing the fresh fruits of L. sicerariain the juicer and was subsequently dried in the oven at 40°-50°C. The parent dried juice extract was then fractionated by using the solvents according to polarity in ascending order i.e. by using chloroform: acetic acid, methanol, pyridine, and water.Each fraction was dried in oven at 40°-50°C. Thin layer chromatography (TLC) used active fraction obtained by column chromatography for further isolation and the isolated compounds (LS_1, LS_2 and LS_3) were tested for anti-hyperlipidemic activity. Allthe extracts significantly increased (p < 0.0001) plasma HDL-Cholesterol and decreased plasma TC, LDL-Cholesterol and TG levels as compared with hyperlipidemic control.