Multicomponent domino reactions in deep eutectic solvent: An efficient strategy to synthesize multisubstituted cyclohexa-1,3-dienamines

摘要

AbstractThe multicomponent domino reactions of ketones, aldehydes and malononitrile in a deep eutectic solvent (DES) were developed. Urea-choline chloride based DES is effective dual solvents/organocatalysts and affording a series of multisubstituted cyclohexa-1,3-dienamines in good to excellent yields under mild conditions. The DES could be easily recycled several times without appreciable loss of activity. The present protocol offers advantages in terms of environmental sustainability and efficient utilization of natural resources, operational simplicity and short reaction times.Graphical abstractDisplay OmittedHighlights?Greener strategy under operational simplicity was reported.?Good to excellent yields of the products.?This approach eliminates the use of hazardous organic solvents and toxic catalysts.?Biorenewable and recyclable solvent]]>