Volumetric and ultrasonic study of l-arginine/l-histidine and gentamicin sulphate in aqueous medium at different temperatures

摘要

The nature of interaction of amino acid with drug are examined from the experimentally measured values of densities, rho and ultrasonic speeds, u of l-arginine and l-histidine in aqueous-gentamicin sulphate (1% and 2% gentamicin sulphate in water, w/w) solvents over the temperature range from 293.15 K to 318.15 K and at atmospheric pressure. From the experimental rho values, the apparent molar volume, V-phi, limiting apparent molar volume, V-phi, transfer volume, V-phi,V- tr, and limiting partial molar expansivity, E-phi, were obtained. Using the u data, acoustic parameters, viz, apparent molar compressibility, K-s,K- phi, limiting apparent molar compressibility, K-s,K- phi, and transfer compressibility, K-s, (phi, tr) have been evaluated. The results have been interpreted in terms of possible solute-solute and solute-solvent interactions. (C) 2020 Elsevier B.V. All rights reserved.