Hyperthermia Temperature of Magnetic Fluid with Superparamagnetic Nanoparticles Subjected to an Alternating Magnetic Field

摘要

This paper conducts the thermal analysis of magnetic fluid with superparamagnetic nanoparticles subjected to an alternating magnetic field. Magnetic fluid hyperthermia (MFH) provides a potential method for cancer treatment, which has fewer side effects than chemotherapy and radiotherapy. Superparamagnetic nanoparticles dispersed in water are suitable for safe application of MFH. A well-defined hyperthermia should only kill the cancer cells without injuring neighbouring normal tissue. A key factor for hyperthermia is to correctly control the alternating magnetic field-induced temperature of the magnetic fluid in the tumour. Therefore, this study develops a thermal transport model combined with a linear response theory of magnetic nanoparticle (MNP) heat dissipation to analyze the effects of parameters on temperatures in the magnetic fluid with superparamagnetic nanoparticles subjected to an alternating magnetic field. The results predicted by this model are compared with the available experimental data and show that the rise rates of temperature with time and temperatures along the radial direction are enhanced by the increase of MNP concentrations in magnetic fluid, the amplitude of magnetic field strength, frequency, and magnetization.