Effect of Achyranthes aspera (Linn) seeds on redox and oxidative status in plasma and selected tissues of rats fed with high doses of fructose.

摘要

Oxidative stress plays an important role as a mediator of damage produced by fructose. The present study reports the effects of A. aspera (Linn) on the liver, kidney lipid peroxidation and antioxidant defence system of rats that are fed with high fructose diet. Male Wistar rats of body weight 100-120 g were divided into four groups containing six rats each. The rats were divided into four groups as Group I (control), Group II (Fructose fed rats), Group III (Fructose fed treated with A. aspera) and Group IV (control treated with A. aspera). Control animals received the control diet containing starch while fructose-fed animals received a fructose-enriched diet (>60% of total calories). Fructose fed rats showed increased lipid peroxidation (TBARS and conjugated dienes) and impaired antioxidant status (SOD, CAT, Cyt 450, NADPH, XO, GSH, GPX). A. aspera is well documented for the presence of phytoactive constituents. Reduction in rate of lipid peroxidation and enhancement in free radical scavenging activity of the herbal seed powder is due to presence of phytoactive constituents.