Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

Lassaletta Alvaro; Zapotocky Michal; Mistry Matthew; Ramaswamy Vijay; Honnorat Marion; Krishnatry Rahul; Stucklin Ana Guerreiro; Zhukova Nataliya; Arnoldo Anthony; Ryall Scott; Ling Catriona; McKeown Tara; Loukides Jim; Cruz Ofelia; de Torres Carmen; Ho Cheng-Ying; Packer Roger J.; Tatevossian Ruth; Qaddoumi Ibrahim; Harreld Julie H.; Dalton James D.; Mulcahy-Levy Jean; Foreman Nicholas; Karajannis Matthias A.; Wang Shiyang; Snuderl Matija; Rao Amulya Nageswara; Giannini Caterina; Kieran Mark; Ligon Keith L.; Garre Maria Luisa; Nozza Paolo; Mascelli Samantha; Raso Alessandro; Mueller Sabine; Nicolaides Theodore; Silva Karen; Perbet Romain; Vasiljevic Alexandre; Conter Cecile Faure; Frappaz Didier; Leary Sarah; Crane Courtney; Chan Aden; Ng Ho-Keung; Shi Zhi-Feng; Mao Ying; Finch Elizabeth; Eisenstat David; Wilson Bev; Carret Anne Sophie; Hauser Peter; Sumerauer David; Krskova Lenka; Larouche Valerie; Fleming Adam; Zelcer Shayna; Jabado Nada; Rutka James T.; Dirks Peter; Taylor Michael D.; Chen Shiyi; Bartels Ute; Huang Annie; Ellison David W.; Bouffet Eric; Hawkins Cynthia; Tabori Uri

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Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

机译：BRAF v600E在儿科低级胶质瘤中的治疗和预后意义

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Purpose BRAF V600E is a potentially highly targetable mutation detected in a subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group of tumors remains unknown.

机译：目的BRAF V600E是在儿科低级胶质瘤（PLGGS）的子集中检测到的潜在高度可定位的突变。在这种不同肿瘤中的生物学和临床疗效仍然未知。

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来源
《Journal of Clinical Oncology》 |2017年第25期|共14页
作者
Lassaletta Alvaro; Zapotocky Michal; Mistry Matthew; Ramaswamy Vijay; Honnorat Marion; Krishnatry Rahul; Stucklin Ana Guerreiro; Zhukova Nataliya; Arnoldo Anthony; Ryall Scott; Ling Catriona; McKeown Tara; Loukides Jim; Cruz Ofelia; de Torres Carmen; Ho Cheng-Ying; Packer Roger J.; Tatevossian Ruth; Qaddoumi Ibrahim; Harreld Julie H.; Dalton James D.; Mulcahy-Levy Jean; Foreman Nicholas; Karajannis Matthias A.; Wang Shiyang; Snuderl Matija; Rao Amulya Nageswara; Giannini Caterina; Kieran Mark; Ligon Keith L.; Garre Maria Luisa; Nozza Paolo; Mascelli Samantha; Raso Alessandro; Mueller Sabine; Nicolaides Theodore; Silva Karen; Perbet Romain; Vasiljevic Alexandre; Conter Cecile Faure; Frappaz Didier; Leary Sarah; Crane Courtney; Chan Aden; Ng Ho-Keung; Shi Zhi-Feng; Mao Ying; Finch Elizabeth; Eisenstat David; Wilson Bev; Carret Anne Sophie; Hauser Peter; Sumerauer David; Krskova Lenka; Larouche Valerie; Fleming Adam; Zelcer Shayna; Jabado Nada; Rutka James T.; Dirks Peter; Taylor Michael D.; Chen Shiyi; Bartels Ute; Huang Annie; Ellison David W.; Bouffet Eric; Hawkins Cynthia; Tabori Uri;
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Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp San Juan Dios Barcelona Spain;

Hosp San Juan Dios Barcelona Spain;

Univ Maryland Sch Med Baltimore MD 21201 USA;

Childrens Natl Hlth Syst Washington DC USA;

St Jude Childrens Res Hosp Memphis TN 38105 USA;

St Jude Childrens Res Hosp Memphis TN 38105 USA;

St Jude Childrens Res Hosp Memphis TN 38105 USA;

St Jude Childrens Res Hosp Memphis TN 38105 USA;

Childrens Hosp Colorado Aurora CO USA;

Childrens Hosp Colorado Aurora CO USA;

NYU Langone Med Ctr New York NY USA;

NYU Langone Med Ctr New York NY USA;

NYU Langone Med Ctr New York NY USA;

Mayo Clin Rochester MN USA;

Mayo Clin Rochester MN USA;

Childrens Hosp Dana Farber Canc Inst Boston MA 02115 USA;

Childrens Hosp Dana Farber Canc Inst Boston MA 02115 USA;

Ist Giannina Gaslini Genoa Italy;

Ist Giannina Gaslini Genoa Italy;

Ist Giannina Gaslini Genoa Italy;

Ist Giannina Gaslini Genoa Italy;

Univ Calif San Francisco San Francisco CA 94143 USA;

Univ Calif San Francisco San Francisco CA 94143 USA;

Hosp Civils Lyon Lyon France;

Hosp Civils Lyon Lyon France;

Inst Pediat Hematol &

Oncol Lyon France;

Inst Pediat Hematol &

Oncol Lyon France;

Inst Pediat Hematol &

Oncol Lyon France;

Seattle Childrens Hosp Seattle WA USA;

Seattle Childrens Hosp Seattle WA USA;

Chinese Univ Hong Kong Hong Kong Hong Kong Peoples R China;

Chinese Univ Hong Kong Hong Kong Hong Kong Peoples R China;

Fudan Univ Huashan Hosp Shanghai Peoples R China;

Fudan Univ Huashan Hosp Shanghai Peoples R China;

Univ N Carolina Sch Med Chapel Hill NC USA;

Univ Alberta Stollery Childrens Hosp Edmonton AB Canada;

Univ Alberta Stollery Childrens Hosp Edmonton AB Canada;

Hosp Sainte Justine Montreal PQ Canada;

Semmelweis Univ Budapest Hungary;

Charles Univ Prague Univ Hosp Motol Med Sch 2 Prague Czech Republic;

Charles Univ Prague Univ Hosp Motol Med Sch 2 Prague Czech Republic;

Univ Quebec Ctr Hosp Quebec City PQ Canada;

McMaster Univ McMaster Childrens Hosp Hamilton ON Canada;

Childrens Hosp Western Ontario London ON Canada;

McGill Univ Montreal PQ Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

St Jude Childrens Res Hosp Memphis TN 38105 USA;

Hosp Sick Children Toronto ON Canada;

Hosp Sick Children Toronto ON Canada;

Univ Toronto Res Inst Div Haematol Oncol 555 Univ Ave Toronto ON M5G 1X8 Canada;

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正文语种 eng
中图分类肿瘤学;
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专利

1. Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas [J] . Lassaletta Alvaro, Zapotocky Michal, Mistry Matthew, Journal of Clinical Oncology . 2017,第25期

机译：BRAF v600E在儿科低级胶质瘤中的治疗和预后意义
2. BRAF V600E Status Alone Is Not Sufficient as a Prognostic Biomarker in Pediatric Low-Grade Glioma [J] . Jones David T. W., Witt Olaf, Pfister Stefan M. Journal of Clinical Oncology . 2018,第1期

机译：单独的BRAF V600E状态不作为儿科低级胶质瘤的预后生物标志物
3. BRAF V600E Status Alone Is Not Sufficient as a Prognostic Biomarker in Pediatric Low-Grade Glioma Reply [J] . Tabori Uri, Bouffet Eric, Hawkins Cynthia E. Journal of Clinical Oncology . 2018,第1期

机译：单独的BRAF V600E状态不作为儿科低级胶质瘤答复的预后生物标志物
4. MACHINE LEARNING FROM CONCEPT TO CLINIC: RELIABLE DETECTION OF BRAF V600E DNA MUTATIONS IN THYROID NODULES USING HIGH-DIMENSIONAL RNA EXPRESSION DATA [C] . JAMES DIGGANS, SU YEON KIM, ZHANZHI HU, Pacific Symposium on Biocomputing . 2015

机译：从概念到诊所的机器学习：使用高尺寸RNA表达数据可靠地检测甲状腺结节中的BRAF V600E DNA突变
5. Development of Nanoliposomes for the Treatment of Braf V600e Mutated Parent and Vemurafenib-Resistant Melanoma [D] . Fu, Yige. 2021

机译：用于治疗BRAF V600E突变父母和vemureafenib抗性黑素瘤的纳米脂质体的研制
6. Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas [O] . Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, -1

机译：BRAF V600E在小儿低度胶质瘤中的治疗和预后意义
7. PD-L1 Expression in Pediatric Low-Grade Gliomas Is Independent of BRAF V600E Mutational Status [O] . Allison M Martin, W Robert Bell, Ming Yuan, 2019

机译：PD-L1在儿科低级胶质瘤中的表达与BRAF V600E突变状况无关
8. Targeting BRAF V600E and Autophagy in Pediatric Brain Tumors. [R] . Levy, J. M. 2015

机译：针对小儿脑肿瘤中的BRaF V600E和自噬。

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

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