Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis DUAL-1 and DUAL-2 Randomized Clinical Trials

Khanna Dinesh; Denton Christopher P.; Merkel Peter A.; Krieg Thomas; Le Brun Franck-Olivier; Marr Angelina; Papadakis Kelly; Pope Janet; Matucci-Cerinic Marco; Furst Daniel E.

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Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis DUAL-1 and DUAL-2 Randomized Clinical Trials

机译：Macitentan对全身硬化双1和双2随机临床试验患者新缺血性数字溃疡开发的影响

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IMPORTANCE Digital ulcers in patients with systemic sclerosis are associated with pain and poor quality of life. Endothelin-1 promotes vasculopathy in systemic sclerosis after macitentan, an endothelin-1 blocker.

机译：系统性硬化症患者的重要性数字溃疡与疼痛和生活质量差有关。内皮素-1促进血管内的血管病变，在Macitentan后，内皮素-1阻断剂。

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《JAMA: the Journal of the American Medical Association》 |2016年第18期|共14页
作者
Khanna Dinesh; Denton Christopher P.; Merkel Peter A.; Krieg Thomas; Le Brun Franck-Olivier; Marr Angelina; Papadakis Kelly; Pope Janet; Matucci-Cerinic Marco; Furst Daniel E.;
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作者单位

Univ Michigan Dept Internal Med Scleroderma Program Ann Arbor MI 48109 USA;

Royal Free Hosp Ctr Rheumatol &

Connect Tissue Dis Pond St London NW3 2QG England;

Univ Penn Div Rheumatol Philadelphia PA 19104 USA;

Univ Cologne Dept Dermatol Cologne Germany;

Actel Pharmaceut Ltd Allschwil Switzerland;

Actel Pharmaceut Ltd Allschwil Switzerland;

Actel Pharmaceut Ltd Allschwil Switzerland;

Univ Western Ontario Dept Med Div Rheumatol London ON Canada;

Univ Florence AOUC Div Rheumatol Dept Expt &

Clin Med Florence Italy;

Univ Calif Los Angeles Div Rheumatol Los Angeles CA USA;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
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入库时间 2022-08-19 19:21:30

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1. Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis DUAL-1 and DUAL-2 Randomized Clinical Trials [J] . Khanna Dinesh, Denton Christopher P., Merkel Peter A., JAMA: the Journal of the American Medical Association . 2016,第18期

机译：Macitentan对全身硬化双1和双2随机临床试验患者新缺血性数字溃疡开发的影响
2. Differences in disability as measured by the Health Assessment Questionnaire between patients with and without digital ulcers in systemic sclerosis: a post hoc analysis of pooled data from two randomised controlled trials in digital ulcers using bosentan. [J] . Zelenietz C, Pope J Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2010,第11期

机译：根据健康评估问卷对患有和不患有数字性溃疡的系统性硬化症患者之间的残疾差异进行的事后分析：使用波生坦对两项数字化溃疡随机对照试验的汇总数据进行事后分析。
3. Bosentan in Clinical Practice for Treating Digital and Other Ischemic Ulcers in Spanish Patients with Systemic Sclerosis: IBER-DU Cohort Study. [J] . Roman Ivorra JA, Simeon CP, Alegre Sancho JJ, The Journal of rheumatology . 2011,第8期

机译：Bosentan在西班牙系统性硬化症患者中治疗数字和其他缺血性溃疡的临床实践：IBER-DU队列研究。
4. Predicting Clinical Status of Patients After an Acute Ischemic Stroke Using Random Forests [C] . Adela Vrtkova International Conference on Information and Digital Technologies . 2017

机译：使用随机林预测急性缺血性脑卒中患者的临床状态
5. A prospective, multicentre, randomized, controlled clinical investigation of dermagraft in patients with venous leg ulcers. [D] . Al-Muhairi, Amna Suhail. 2004

机译：静脉曲张溃疡患者皮肤移植的前瞻性，多中心，随机对照临床研究。
6. Clinical characteristics and predictors of gangrene in patients with systemic sclerosis and digital ulcers in the Digital Ulcer Outcome Registry: a prospective observational cohort [O] . Yannick Allanore, Christopher P Denton, Thomas Krieg, -1

机译：系统性硬化症和数字性溃疡患者坏疽的临床特征和预测因子在数字溃疡结果登记处：前瞻性观察性队列
7. Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis: DUAL-1 and DUAL-2 Randomized Clinical Trials. [O] . Khanna D, Denton CP, Merkel PA, 2016

机译：Macitentan对系统性硬化症患者新缺血性数字溃疡发展的影响：DUAL-1和DUAL-2随机临床试验。

Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis DUAL-1 and DUAL-2 Randomized Clinical Trials

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