Association of Genetic Variants Related to Combined Exposure to Lower Low-Density Lipoproteins and Lower Systolic Blood Pressure With Lifetime Risk of Cardiovascular Disease

Ference Brian A.; Bhatt Deepak L.; Catapano Alberico L.; Packard Chris J.; Graham Ian; Kaptoge Stephen; Ference Thatcher B.; Guo Qi; Laufs Ulrich; Ruff Christian T.; Cupido Arjen; Hovingh G. Kees; Danesh John; Holmes Michael V.; Smith George Davey; Ray Kausik K.; Nicholls Stephen J.; Sabatine Marc S.

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Association of Genetic Variants Related to Combined Exposure to Lower Low-Density Lipoproteins and Lower Systolic Blood Pressure With Lifetime Risk of Cardiovascular Disease

机译：遗传变体与较低低密度脂蛋白结合的遗传变异和较低的收缩压与心血管疾病的寿命风险降低

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IMPORTANCE The relationship between exposure to lower low-density lipoprotein cholesterol (LDL-C) and lower systolic blood pressure (SBP) with the risk of cardiovascular disease has not been reliably quantified.

机译：重要性尚未可靠地定量暴露于低密度脂蛋白胆固醇（LDL-C）和较低的收缩压（SBP）与心血管疾病风险的关系。

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来源
《JAMA: the Journal of the American Medical Association》 |2019年第14期|共11页
作者
Ference Brian A.; Bhatt Deepak L.; Catapano Alberico L.; Packard Chris J.; Graham Ian; Kaptoge Stephen; Ference Thatcher B.; Guo Qi; Laufs Ulrich; Ruff Christian T.; Cupido Arjen; Hovingh G. Kees; Danesh John; Holmes Michael V.; Smith George Davey; Ray Kausik K.; Nicholls Stephen J.; Sabatine Marc S.;
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作者单位

Univ Cambridge Ctr Nat Randomized Trials Two Worts Causeway Cambridge CB1 8RN England;

Harvard Med Sch Brigham &

Womens Hosp Heart &

Vasc Ctr Boston MA 02115 USA;

Univ Milan Multimed IRCCS Dept Pharmacol &

Biomol Sci Milan Italy;

Univ Glasgow Inst Cardiovasc &

Med Sci Glasgow Lanark Scotland;

Trinity Coll Dublin Sch Med Dublin Ireland;

Univ Cambridge Dept Publ Hlth &

Primary Care MRC BHF Cardiovasc Epidemiol Unit Cambridge England;

Univ Cambridge Ctr Nat Randomized Trials Two Worts Causeway Cambridge CB1 8RN England;

Univ Cambridge Ctr Nat Randomized Trials Two Worts Causeway Cambridge CB1 8RN England;

Univ Leipzig Dept Cardiol Leipzig Germany;

Harvard Med Sch Brigham &

Womens Hosp Div Cardiovasc Med Thrombolysis Myocardial Infarct TIMI;

Univ Cambridge Ctr Nat Randomized Trials Two Worts Causeway Cambridge CB1 8RN England;

Univ Amsterdam Acad Med Ctr Dept Vasc Med Amsterdam Netherlands;

Univ Cambridge Dept Publ Hlth &

Primary Care MRC BHF Cardiovasc Epidemiol Unit Cambridge England;

Univ Oxford Nuffield Dept Populat Hlth Clin Trial Serv Unit MRC Populat Hlth Res Unit Oxford;

Univ Bristol MRC Integrat Epidemiol Unit Bristol Avon England;

Imperial Coll London Imperial Ctr Cardiovasc Dis Prevent Sch Publ Hlth Dept Primary Care &

Publ;

Monash Univ Melbourne Vic Australia;

Harvard Med Sch Brigham &

Womens Hosp Div Cardiovasc Med Thrombolysis Myocardial Infarct TIMI;

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正文语种 eng
中图分类医药、卫生;
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专利

1. Association of Genetic Variants Related to Combined Exposure to Lower Low-Density Lipoproteins and Lower Systolic Blood Pressure With Lifetime Risk of Cardiovascular Disease [J] . Ference Brian A., Bhatt Deepak L., Catapano Alberico L., JAMA: the Journal of the American Medical Association . 2019,第14期

机译：遗传变体与较低低密度脂蛋白结合的遗传变异和较低的收缩压与心血管疾病的寿命风险降低
2. Intensively Lowering Both Low-Density Lipoprotein Cholesterol and Blood Pressure Does Not Reduce Cardiovascular Risk in Japanese Coronary Artery Disease Patients [J] . Takahide Kohro, Tsutomu Yamazaki, Tohru Izumi, Circulation journal . 2011,第9期

机译：强烈降低低密度脂蛋白胆固醇和血压均不能降低日本冠状动脉疾病患者的心血管风险
3. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. [J] . Egert S., Bosy-Westphal A., Seiberi J., The British Journal of Nutrition . 2009,第7期

机译：槲皮素可降低患有高心血管疾病风险表型的超重受试者的收缩压和血浆氧化的低密度脂蛋白浓度：一项双盲，安慰剂对照的交叉研究。
4. The Postmenopausal Hormone Replacement Therapy Alters Lipoprotein Composition Leading to an Overestimation of its Low-Density Lipoprotein Cholesterol Lowering Effect [C] . J.L. Vicira, E.H. Moriguchi, M.E. Gomes, International Congress on Coronary Artery Disease . 2003

机译：绝经后激素替代疗法改变了脂蛋白组合物，导致其低密度脂蛋白胆固醇降低效果的高估
5. Association of blood pressure and gait speed in hypertensive older adults: The systolic blood pressure intervention trial (SPRINT) [D] . Williams, Julie A. 2014

机译：高血压老年人的血压和步态速度协会：收缩压干预试验（Sprint）
6. Identification of the Functional Variant(s) that Explain the Low-Density Lipoprotein Receptor (LDLR) GWAS SNP rs6511720 Association with Lower LDL-C and Risk of CHD [O] . Roaa Hani Fairoozy, Jon White, Jutta Palmen, 2011

机译：鉴定可解释低密度脂蛋白受体（LDLR）GWAS SNP rs6511720与较低LDL-C和冠心病风险相关的功能变体
7. Association of Genetic Variants Related to Combined Exposure to Lower Low-Density Lipoproteins and Lower Systolic Blood Pressure With Lifetime Risk of Cardiovascular Disease [O] . Brian A. Ference, Deepak L. Bhatt, Alberico L. Catapano, 2019

机译：遗传变体与较低低密度脂蛋白结合的遗传变异和较低的收缩压与心血管疾病的寿命风险降低

Association of Genetic Variants Related to Combined Exposure to Lower Low-Density Lipoproteins and Lower Systolic Blood Pressure With Lifetime Risk of Cardiovascular Disease

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