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首页> 外文期刊>Current Protocols in Mouse Biology >Inducing and Characterizing Liver Regeneration in Mice: Reliable Models, Essential “Readouts” and Critical Perspectives
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Inducing and Characterizing Liver Regeneration in Mice: Reliable Models, Essential “Readouts” and Critical Perspectives

机译:诱导和表征小鼠肝脏再生:可靠的模型,重要的“读数”和关键观点

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摘要

Elucidating the molecular circuitry that regulates regenerative responses in mammals has recently attracted considerable attention because of its emerging impact on modern bioengineering, tissue replacement technologies, and organ transplantation. Theliver is one of the few organs of the adult body that exhibits a prominent regenerative capacity in response to toxic injury, viral infection, or surgical resection. Over the years, mechanistic insights into the liver's regenerative potential have beenprovided by rodent models of chemical liver injury or surgical resection that faithfully recapitulate hallmarks of human pathophysiology and trigger robust hepatocyte proliferation leading to organ restoration. The advent of mouse transgenics has undeniably catalyzed the wider application of such models for researching liver pathobiology. This article provides a comprehensive overview of the most reliable and widely applied murine models of liver regeneration and also discusses helpful hints, considerations, and limitations related to the use of these models in liver regeneration studies.
机译:阐明调节哺乳动物再生反应的分子电路,由于其对现代生物工程,组织替代技术和器官移植的新兴影响,最近引起了相当大的关注。肝脏是成年人体中为毒性损伤,病毒感染或手术切除而显示出显着再生能力的少数器官之一。多年来,化学啮齿动物模型或外科手术切除的啮齿动物模型已经提供了对肝脏再生潜力的机械洞察力,这些模型忠实地概括了人类病理生理学的特征并触发了健壮的肝细胞增殖,从而导致器官恢复。小鼠转基因技术的出现无可否认地催化了此类模型在肝脏病理生物学研究中的广泛应用。本文全面概述了最可靠和应用最广泛的小鼠肝再生模型,并讨论了与在肝再生研究中使用这些模型有关的有用提示,考虑因素和局限性。

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