A novel therapeutic vaccine composed of a rearranged human papillomavirus type 16 E6/E7 fusion protein and Fms-like tyrosine kinase-3 ligand induces CD8 ce:sup loc='post'>+/ce:sup> T cell responses and antitumor effect

Jianqiang Li; Si Chen; Jun Ge; Feng Lu; Sulin Ren; Zhiqiang Zhao; Xiuying Pu; Xiaoxiao Chen; Jiaojiao Sun; Yueqing Gu

首页> 外文期刊>Vaccine >A novel therapeutic vaccine composed of a rearranged human papillomavirus type 16 E6/E7 fusion protein and Fms-like tyrosine kinase-3 ligand induces CD8 ce:sup loc='post'>+/ce:sup> T cell responses and antitumor effect

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A novel therapeutic vaccine composed of a rearranged human papillomavirus type 16 E6/E7 fusion protein and Fms-like tyrosine kinase-3 ligand induces CD8 ce:sup loc='post'>+/ce:sup> T cell responses and antitumor effect

机译：一种新的治疗性疫苗，由重排人乳头瘤病毒16型E6 / E7融合蛋白和FMS样酪氨酸激酶-3配体组成，诱导CD8＆ ce：sup =“post”> + + +＆ / ce：sup> t细胞反应和抗肿瘤效果

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来源
《Vaccine》 |2017年第47期|共9页
作者
Jianqiang Li; Si Chen; Jun Ge; Feng Lu; Sulin Ren; Zhiqiang Zhao; Xiuying Pu; Xiaoxiao Chen; Jiaojiao Sun; Yueqing Gu;
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作者单位

Jiangsu Theravac Bio-pharmaceutical CO. Ltd;

Jiangsu Theravac Bio-pharmaceutical CO. Ltd;

Jiangsu Theravac Bio-pharmaceutical CO. Ltd;

Jiangsu Theravac Bio-pharmaceutical CO. Ltd;

Jiangsu Theravac Bio-pharmaceutical CO. Ltd;

Suzhou Yuankang Bio-pharmaceutical Co. Ltd.;

Suzhou Yuankang Bio-pharmaceutical Co. Ltd.;

Jiangsu Theravac Bio-pharmaceutical CO. Ltd;

Jiangsu Theravac Bio-pharmaceutical CO. Ltd;

China Pharmaceutical University;

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正文语种 other
中图分类医学免疫学;
关键词
Human papillomavirus (HPV); E6; E7; Flt3l; Therapeutic protein vaccine; Antitumor effect;

机译：人乳头瘤病毒（HPV）;E6;E7;FLT3L;治疗蛋白质疫苗;抗肿瘤效果;

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1. A novel therapeutic vaccine composed of a rearranged human papillomavirus type 16 E6/E7 fusion protein and Fms-like tyrosine kinase-3 ligand induces CD8 ce:sup loc="post">+/ce:sup> T cell responses and antitumor effect [J] . Jianqiang Li, Si Chen, Jun Ge, Vaccine . 2017,第47期

机译：一种新的治疗性疫苗，由重排人乳头瘤病毒16型E6 / E7融合蛋白和FMS样酪氨酸激酶-3配体组成，诱导CD8＆ ce：sup =“post”> + + +＆ / ce：sup> t细胞反应和抗肿瘤效果
2. Purified herpes simplex type 1 glycoprotein D (gD) genetically fused with the type 16 human papillomavirus E7 oncoprotein enhances antigen-specific CD8+ T cell responses and confers protective antitumor immunity. [J] . Porchia BF, Diniz MO, Cariri FA, Molecular pharmaceutics . 2011,第6期

机译：与16型人乳头瘤病毒E7癌基因遗传融合的纯化的单纯性1型疱疹糖蛋白D（gD）可增强抗原特异性CD8 + T细胞反应并赋予保护性抗肿瘤免疫力。
3. Intranasal immunization with synthetic peptides corresponding to the E6 and E7 oncoproteins of human papillomavirus type 16 induces systemic and mucosal cellular immune responses and tumor protection [J] . Manuri PR, Nehete B, Nehete PN, Vaccine . 2007,第17期

机译：用与人乳头瘤病毒16型的E6和E7癌蛋白相对应的合成肽进行鼻内免疫可诱导全身和粘膜细胞免疫应答并保护肿瘤
4. Phylogenetic Study of L1 Protein Human Papillomavirus Type 16 from Cervical Cancer Patients in Bandung [C] . Fitri Rahmi Fadhilah, Ani Melani Maskoen, Edhyana Sahiratmadja, Molecular Medicine TRI-CON. . 2014

机译：L1蛋白人乳头瘤病毒16型来自宫颈癌患者L1蛋白人乳头瘤病毒的系统发育研究
5. Investigation of the mechanism by which the human papillomavirus type-16 *E6 oncoprotein induces telomerase in epithelial cells. [D] . Gewin, Lindy. 2004

机译：人乳头瘤病毒16型* E6癌蛋白诱导上皮细胞端粒酶机制的研究。
6. Intranasal Immunization with synthetic peptides corresponding to the E6 and E7 oncoproteins of Human Papillomavirus type 16 induces systemic and mucosal cellular immune responses and tumor protection [O] . Pallavi R. Manuri, Bharti Nehete, Pramod N. Nehete, -1

机译：用与人乳头瘤病毒16型的E6和E7癌蛋白相对应的合成肽进行鼻内免疫可诱导全身和粘膜细胞免疫应答并保护肿瘤
7. Low-Dose Adenovirus Vaccine Encoding Chimeric Hepatitis B Virus Surface Antigen-Human Papillomavirus Type 16 E7 Proteins Induces Enhanced E7-Specific Antibody and Cytotoxic T-Cell Responses [O] . Báez-Astúa, Andrés, Herráez-Hernández, Elsa, Garbi, Natalio, 2005

机译：编码嵌合型乙型肝炎病毒表面抗原的小剂量腺病毒疫苗人乳头瘤病毒16型E7蛋白诱导增强的E7特异性抗体和细胞毒性T细胞反应。
8. Decreased Migration of Langerhans Precursor-Like Cells in Response to Human Keratinocytes Expressing HPV-16 E6/E7 is Related to Reduced Macrophage Inflammatory Protein-3Alpha Production [R] . Guess, J. C. , McCance, D. J. 2005

机译：降低朗格汉斯前体样细胞的迁移响应人类角质形成细胞表达HpV-16 E6 / E7与减少的巨噬细胞炎症蛋白-3α生成相关

A novel therapeutic vaccine composed of a rearranged human papillomavirus type 16 E6/E7 fusion protein and Fms-like tyrosine kinase-3 ligand induces CD8 ce:sup loc='post'>+/ce:sup> T cell responses and antitumor effect

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